The Revolution of Brix 3000 as Chemomechanical Caries Removal (Cmcr) Agent, A Scoping Review

Aninda Kartika Dewi, Meirina Gartika

Abstract


Background: Traditional caries removal techniques, like using a vibrating drill, have several drawbacks, including unpleasant sensations, heat that can irritate dental pulp, the need for local anesthesia, high energy consumption, and environmental concerns. A new method, CMCR (chemomechanical caries removal) with Brix 3000, aims to address these issues. It is minimally invasive, painless, and comfortable, promoting a positive attitude towards dental care, especially for pediatric patients, those with anxiety or fear, and high-risk medical patients. Objective: This literature review examines the use of Brix 3000 gel for chemomechanical caries removal. Methods: The study uses a scoping review method, conducting a comprehensive literature search on PubMed, EBSCO, ScienceDirect, Scopus, ClinicalTrials.gov, and Google Scholar databases. The search focused on articles from the last 10 years using keywords like "chemomechanical caries removal," "Papain Based Gel," "Brix 3000," and "Dental caries." Results: Brix 3000 is the latest effective, efficient, and non-cytotoxic CMCR method. It has a shorter application time and lower cytotoxicity compared to other methods. It is the only CMCR agent using Encapsulating Buffer Emulsion (EBE) technology, enhancing proteolysis to remove degraded collagen from infected dentin. Brix 3000 is easy to use, requires no special instruments, offers patient comfort, does not need local anesthesia or drills, and does not irritate healthy tissue. Conclusion: Brix 3000 gel is an effective and efficient chemomechanical agent for caries removal.

Keywords


Chemomechanical caries removal (CMCR), Dental caries, Dental pulp protection, Pediatric dentistry

Full Text:

PDF

References


Gannam CV, Chin KL, Gandhi RP. Caries Risk Assessment. Gent Dent. 2018;66(6):12-17.

Marlindayanti, Hanum NA, Ismalayani, Heriyanto Y. Manajemen Pencegahan Karies. Kediri: Penerbit Lembaga Chakra Brahmanda Lentera; 2022.

Kidd E, Fejerskov O. Essentials of Dental Caries. 4th ed. United Kingdom: Oxford University Press; 2016.

Ismail MMM, Al Haidar AHMJ. Evaluation of The Efficacy of Caries Removal Using Papain Gel (Brix 3000) and Smart Preparation Bur (In Vivo Comparative Study). J Pharm Sci & Res. 2019;11(2):444-449.

Eden E, Frencken J, Gao S, Horst JA, Innes N. Managing Dental Caries Against The Backdrop of Covid-19: Approaches to Reduce Aerosol Generation. British Dental Journal. 2020;229(7):411-416.

Meyfarth S, Cassano K, Warol F, Santos MD, Scarparo A. A New Efficient Agent to Chemo-Mechanical Caries Removal. Brazillian Journal of Dentistry. 2020; 77: e1946.

Alkhouli MM, Al Nesser SF, Bshara NG, AlMidani AN, Comisi JC. Comparing The Efficacies of Two Chemo-mechanical Caries Removal Agents (2,25% Sodium Hypochlorite Gel and Brix 3000), in Caries Removal and Patient Cooperation: A Randomized Controlled Clinical Trial. Journal of Dentistry. 2020;93:103280.

Gharla BK. Green Dentistry; Ecofriendly Dentistry; Benefical for Patients, Benefical for Environment. Annals and Essencens of Dentistry. 2012;IV(2):72-74.

Sachdeva A, Sharma A, Bhateja S, Arora G. Green Dentistry: A Review. J Dent Oral Biol. 2018;3(6):1144.

Aggarwal VP, Kakkar A, Singh S. Go Green: A New Prospective in Dentistry. MOJ Curr Res & Rev. 2017;I(I):7-10.

Salim RC, Asia A. Gambaran Tingkat Pengetahuan Mahasiswa Fakultas Kedokteran Gigi Universitas Trisakti Tentang Konsep Green Dentistry. JKGT. 2021;3(1):51-57.

Damle SG. Eco-friendly Green Dentistry: The Future of Dentistry?. Contemp Clin Dent. 2016;7:423-5.

Inamdar MS, Chole DG, Bakle SS, Gandhi NP, Hatte NR, Rao MP. Comparative Evaluation of Brix3000, Carie Care, and Smart Burs in Caries Excavation: An in Vivo Study. J Conserv Dent. 2020;23(2):163-168.

Duman C, Kalaoglu EE, Capan BS, Egil E. Comparison of Two Aerosol-Free Caries Removal Methods: A Split-Mouth Randomized Clinical Trial. Cumhuriyet Den J. 2021;24(3):266-273.

Gupta N, Chowdhary N, Reddy VR, Kiran NK, Peddi R, Kumar M. Evalution of Caries Removal Efficacy Using BRIX 3000 and Atraumatic Restorative Treatment in Primary Molars: A Clinical Comparative Study. The Journal of Contemporary Dental Practice. 2022;23(4):419-424.

Elwazeer AE, Abdallah AE, Abbas AN. Clinical and Radiographic Evaluation of 2.25% Sodium Hypochlorite Gel and Brix 3000 in Caries Removing of Deciduous Teeth. Al-Azhar Journal of Dental Science. 2023;26(3):401-411.

Santos TML, Brescian E, Matos FS, Camargo SEA, Hidalgo APT, Rivera LMT, et al. Comparison between Conventional and Chemomechanical Approaches for The Removal of Carious Dentin: An in Vitro Study. Scientific Reports. 2020;10:8127.

Gunjal, P., Chauhan, R. S., Tirupathi, S., Patil, V., & Kothari, P. (2022). Comparative evaluation of microhardness of residual dentin in primary molars following caries removal with chemomechanical agent (BRIX 3000) and polymer burs (ss white): In vitro study. International Journal of Health Sciences, 6(S8), 3516–3530.

Pires PM, et al. Tridimensional Roughness and Morphology of Sound Dentin Surfaces after Papain-Gel Treatment. Dentistry 3000. 2022;1:a001. doi:10.5195/d3000.2022.176.

Melo M, et al. Dentin Surface Morphology According to Caries Removal Method and Subsequent Acid Etching. SSRN:http://dx.doi.org/10.2139/ssrn.4474163 .

Fatima N, Mustilwar R, Paul R, Chauhan PS, Mostafa D, Dhopte A. Minimal Invasive Dentistry: Areview. International Journal of Health Sciences. 2022;6(S1):13062-13077.

Chatterjee AN, Das L, Khushboo, Biswas R, Saha S, Sarkar S. Chemomechanical Caries Removal with Respect to COVID-19 in Dentistry. International Journal of Research and Review. 2020;7(11):517-523.

Ismail MMM, Al Haidar AHMJ. Impact of Brix 3000 and Conventional Restorative Treatment on Pain Reaction during Caries Removal among Group of Children in Baghdad City. J Bagh College Dentistry. 2019;3(2):7-13.

Prabhav C, Anuja JM, Garima C. Chemomechanical Caries Removal with Brix 3000 in Primary Molar Tooth: A Case Report. International Journal of Current Medical and Pharmaceutical Research. 2019:5(11(A)):pp.4740-4742.

De Souza TF, Martins ML, Silva CMT, Goncalves AF, Maia LC. Treatment Time, Pain Experience and Acceptability of The Technique for Caries Removal in Primary Teeth Using The ART Approach with or without Brix3000tm Papain Gel: A Preliminary Randomised Controlled Clinical Trial. European Archives of Pediatric Dentistry. 2022;23:777-785.

Dobboletta M. Dental Gel Composition of Papain for The Atraumatic Treatment of Caries and Method of Preparing Same. WO2015179463A1 (Patent) 2015.

Torresi FN., Besereni L. Effectiveness of Papain as Chemomechanical Caries Removal Method in Adults. J Rev Assoc Paul cir Dent 2017;71(3):266-9.

Lazarova Z, Rashkova M, Gergova R, Tsitou VMS. Antimicrobial Effect of A Means for Enzyme Excavation (Brix 3000) and Photodynamic Therapy in Carious Lesions of Primary Teeth - In Vitro Experiment. Journal of IMAB. 2021;27(4):4048-4051.




DOI: https://doi.org/10.24815/jds.v9i1.40339

Article Metrics

Abstract view : 0 times
PDF - 0 times

Refbacks

  • There are currently no refbacks.


 

Indexed by:

JDS JDS JDS JDS JDS JDS

JDS JDS JDS JDS JDS JDS

JDS 

 
Tools:

JDS JDS JDS JDS JDS JDS

JDS JDS JDS

All papers published in FKG  USK Press are licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

 

Social Media: