THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET

Dwi Anggara Putri, Yulia Yusrini Djabir, Muhammad Akbar Bahar, Gemini Alam, Latifah Rahman, Muhammad Aswad, Muhammad Aryadi Arsyad

Abstract


This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 µg/kg levonorgestrel/3.1 µg/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats’ body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P<0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats’ HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.


Keywords


Oral contraception; high fat diet; lipid profile; statin; fibrate

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References


Aasare, G. A., Santa, S., Angala, R. A., Asiedu, B., Afriyie, D., & Amoah, A. G. (2014). Effect of hormonal contraceptives on lipid profile and the risk indices for cardiovascular disease in a ghanaian community. International Journal of Women’s Health, 6(1), 597–603. https://doi.org/10.2147/IJWH.S59852

Al-Juhaishi, A. M. R., Al-Shehristani, R. M. M., & Al-Obaidi, Z. M. J. (2018). The correlation of the use of oral contraceptive pills and the risk of ischemic heart disease in perimenopausal women. Journal of Pharmaceutical Sciences and Research, 10(6), 1464–1467.

Arsyad, A., Idris, I., Rasyid, A. A., Usman, R. A., Faradillah, K. R., Latif, W. O. U., Lubis, Z. I., Aminuddin, A., Yustisia, I., & Djabir, Y. Y. (2020). Long-Term Ketogenic Diet Induces Metabolic Acidosis, Anemia, and Oxidative Stress in Healthy Wistar Rats. Journal of Nutrition and Metabolism, 2020. https://doi.org/10.1155/2020/3642035

Cani, P. D., Bibiloni, R., Knauf, C., Neyrinck, A. M., & Delzenne, N. M. (2008). Changes in Gut Microbiota Control Metabolic Diet – Induced Obesity and Diabetes in Mice. Diabetes 57 (6): 1470-1481. https://doi.org/10.2337/db07-1403.

Chahyanto, B. A., Marliyati, S. A., & Winarsih, W. (2016). Efek Diet Tinggi Kolesterol Terhadap Peningkatan Kolesterol Darah , Gambaran Histopatologi Hati , dan Bobot Badan Kelinci New Zealand White Jantan. 34(1), 50–59.

Chen, Y. P., Chang, K. C., Tseng, W. K., Yin, W. H., Chen, J. W., Lee, Y. T., & Wu, C. C. (2013). Increased rosuvastatin dose versus concomitant fenofibrate and rosuvastatin therapy to achieve lipid goal in patients with diabetes or atherosclerosis with metabolic syndrome. Acta Cardiologica Sinica, 29(5), 421–428.

Dilshad, H., Ismail, R., Naveed, S., Usmanghani, K., Alam, M. T., & Sarwar, G. (2016). Effect of hormonal contraceptives on serum lipids: A prospective study. Pakistan Journal of Pharmaceutical Sciences, 29(4), 1379–1382.

Dixit, R., & Jagan, S. (2016). Comparative Study of Atorvastatin and Rosuvastatin in Combination with Fenofibrate in mixed Hyperlipidemia. International Journal of Pharmacology and Clinical Sciences, 5(1), 25–31. https://doi.org/10.5530/ijpcs.5.1.5

Hardiningsih, R., & Nurhidayat, N. (2006). Pengaruh Pemberian Pakan Hiperkolesterolemia terhadap Bobot Badan Tikus Putih Wistar yang Diberi Bakteri Asam Laktat. Biodiversitas, 7, 127–130. https://doi.org/10.13057/biodiv/d070207

Kim, Kisok; Park, H. (2012). Effect of oral contraceptive use on lipid profile in Korean women aged 35–55 years. Contraception, 86(5), 500–505

Lestari, H., Rita, R. S., & Yusrawati. (2019). Perbandingan Kadar Kolesterol Total Dan Hdl Antara Akseptor Kb Pil Kombinasi Dengan Dmpa. Indonesia Jurnal Kebidanan, 3(1), 1–10.

Lina Y, Herianus L, S. P. M. (2017). Pengaruh diet beras hitam, kacang merah dan daun kelor (betamelor) terhadap perubahan berat badan tikus. Kupang Journal of Food and Nutrition Research. 1(1): 1–6.

Luvai, A., Mbagaya, W., Hall, A. S., & Barth, J. H. (2012). Rosuvastatin: A review of the pharmacology and clinical effectiveness in cardiovascular disease. Clinical Medicine Insights: Cardiology, 6, 17–33. https://doi.org/10.4137/CMC.S4324

Mulazimah. (2017). Perbedaan Pengaruh Penggunaan Kontrasepsi Pil Kombinasi Dan Kontrasepsi Iud Terhadap Perubahan Berat Badan Pada Akseptor Di Wilayah Puskesmas Sukorame. Jurnal Nusantara Medika, 2(1), 1–10.

Stocco, B. Fumagalli, H.F., Franceschini, S.A, Machado, C.M.M, Toloi, M, R T (2013). The Effect of Different Contraceptive Drugs on the Lipid Profile of Brazilian Women. Pharmaceutica Analytica Acta, 04(01), 1–4.

https://doi.org/10.4172/2153-2435.1000208

Subashini C. Thambiah. (2017). Effects of Different Types of Statins on Lipid Profile: A Perspective on Asians. International Journal of Endocrinology and Metabolism. 15(2), 1–12. https://doi.org/10.5812/ijem.43319.

Sufa, B., Abebe, G., & Cheneke, W. (2019). Dyslipidemia and associated factors among women using hormonal contraceptives in Harar town, Eastern Ethiopia. BMC Research Notes, 12(1), 1–7. https://doi.org/10.1186/s13104-019-4148-9

Tsimihodimos, V., Miltiadous, G., Daskalopoulou, S. S., Mikhailidis, D. P., & Elisaf, M. S. (2005). Fenofibrate : Metabolic and Pleiotropic Effects. Current Vascular Pharmacology. https://doi.org/10.2174/1570161052773942

Ward, N. C., Watts, G. F., & Eckel, R. H. (2019). Statin Toxicity: Mechanistic Insights and Clinical Implications. Circulation Research, 124(2), 328–350. https://doi.org/10.1161/CIRCRESAHA.118.312782




DOI: https://doi.org/10.21157/j.ked.hewan.v16i3.22196

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