Tutik Wresdiyati, Hamzah Alfarisi, Anisya Saeila Putri, Puri Adzrok Abidah, Made Darawati, Sandra Aziz, Siti Sa’diah, Made Astawan, Koekoeh Santoso


This study aimed to analyze flavonoid and 6-gingerol content and to test the hypoglycemic effects of industrial-grade Cajanus cajan (pigeon pea) leaf and Zingiber officinale rhizome (ginger) extracts on hyperglycemic rats. Extraction utilized maceration with 70% alcohol at PT. Insular Multi Natural. Extracts were characterized and analyzed for flavonoids and 6-gingerol content. Hypoglycemic activity was assessed using the oral glucose tolerance test (OGTT) on rats with induced hyperglycemia via 90% sucrose solution. The results indicated higher flavonoid content in C. cajan leaf extract (4090.09±338.23 mg/100 g) compared to Z. officinale extract (622.74±203.39 mg/100 g), while gingerol content in Z. officinale extract was 701.52±4.42 mg/100 g. This study concluded that combination of industrial-grade pigeon pea leaves extract and ginger extract reduce the level of blood glucose in hyperglycemic model rats at all combination dose (150:150, 200:100, and 100:200 mg/kg BW). The combination dose of 200:100 mg/kg BW showed the best blood glucose level profile.


blood glucose; flavonoid; ginger; 6-gingerol; pigeon pea leaves

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