Fadeli Bermani, Raden Harry Soehartono, Guntur Berlian, Riki Siswandi


This study aims to determine the effectiveness of combination of snakehead fish, ginger and meniran extract (GTM) on healing wounds after ovariohysterectomy (OH) in cats. Twenty healthy female cats aged 1-4 years, weighed 2-4 kg were divided into three groups with different doses of GTM and compared with the group without treatment (n= 5 cats/group). The GTM dose was extrapolated from the human dose using allometric scaling, with the basal dose for G:T:M were 40:3.2:4.8 mg/kg BW (group 1, GTM1x). Treatment groups 2 (GTM2x) and 3 (GTM4x) were given a dose of GTM that was multiplied by 2 and 4 of the basal doses, respectively. OH was performed via a flank approach with the same operator and anesthesia. Discharge, swelling and erythema scores were significantly lower on days 3, 4 and 5 post-operativeamong all GTM groups compared with control. Pain evaluation using Baseline Tactile Semmes Monofilaments showed significantly lower in GTM2x and GTM4x compared to GTM1x and control. The 4A-vet pain scale showed lower pain in GTM2x from 1 to 5 days postoperative. The number of leukocytes, erythrocytes and platelets was in the normal range indicates the absence of postoperative infection. Postoperative albumin levels showed a significantly higher difference in GTM2x compared to control. The treatment given GTM2x showed the fastest healing interval (3.2±0.44 days). The combination of GTM can reduce pain, reduce wound scores and accelerate post-OH wound healing with the most effective dose was GTM2x. ________________________________________________________________


cat, meniran, ovariohysterectomy, snakehead fish, temulawak

Full Text:



Aisyatussoffi N, Abdulgani N. 2013. Pengaruh pemberian ekstrak ikan gabus pada struktur histologi pankreas dan kadar glukosa darah mencit hiperglikemik. Jurnal Sains Dan Seni Pomits, 2(1): 2337–3520.

Berlian G, Riani C, Kurniati NF, Rachmawati H. 2023. Peptide derived C. striata albumin as a natural angiotensin-converting enzyme inhibitor. Heliyon 9, 9(5):1-10.

Bihari S, Bannard-Smith J, Bellomo R. 2020. Albumin as a drug: its biological effects beyond volume expansion. Crit Care Resusc, 22(3):257-265.

Coe RJ, Grint NJ, Tivers MS, Hotston Moore A, Holt PE. 2006. Comparison of flank and midline approaches to the ovariohysterectomy of cats. Veterinary Record, 159(3):309-313.

Detora M, Mccarthy RJ. 2011. Ovariohysterectomy versus ovariectomy for elective. Journal of the American Veterinary Medical Association, 239(11):1409–1412.

Fitriansyah I, Djanas D, Bachtiar H. 2021. The Effect of Oral Albumin Intake on Serum Albumin Levels in Preeclamsia Patients With Hypoalbuminemia in RSUP Dr. M. Djamil Padang. Andalas Obstetrics and Gynecology Journal, 5(1):69-81.

Franzotti EM, Santos CVF, Rodrigues HMSL, Mourao RHV, Andrade MR, Antonioli AR. 2000. Anti inflammatory, analgesic activity and acute toxicity of Sida cardifolia L. (Malva-branca). Journal of Ethnopharmacology, 72 : 237-278.

Grandemange E, Fournel S, Woehrlé F. 2013. Efficacy and safety of cimicoxib in the control of perioperative pain in dogs. Journal Small Animal Practice, 54(6):304-312.

Grint NJ, Murison PJ, Coe RJ, Pearson AEW. 2006. Assessment of the influence of surgical technique on postoperative pain and wound tenderness in cats following ovariohysterectomy. Journal of Feline Medicine and Surgery, 8(1):15-21

Harding KG. 2008. Wound Exudate and the Role of Dressings. Int Wound Journal, 5(1):1-12.

Hikmah U, Triastuti A. 2022. Mechanism and immunomodulator bioactive compounds of Phyllanthus niruri (meniran). Scientific Journal of Pharmacy, 18 (2) : 205-218.

Hussain Y, Abdullah, Khan F, Alsharif KF, Alzahrani KJ, Saso L, Khan H. 2022. Regulatory Effects of Curcumin on Platelets:An Update and Future. Biomedicines, 10(12) :1-13.

Kadir AA, Kadir AA, Hamid RA, Jais AMM, Omar J, Sadagatullah AN, Badrin S, Win TT, Sirajudeen KNS, Salleh A. 2019. Evaluation of Chondroprotective Activity of Channa striatus in Rabbit Osteoarthritis Model. BioMed Research International, 1-6.

Kiani FA, Kachiwal AB, Shah MG, Nizamani ZA, Khand FM, Lochi GM, Haseeb A, Khokbar AM, Oad A, Ansari MI. 2014. Comparative Study on Midline and Flank Approaches for Ovariohystrectomy in Cats. Journal of Agriculture and Food Technology, 4(2):21-31.

Li S, Renick P, Senkowsky J, Nair A, Tang L. 2021. Diagnostics for wound infections. Advances in wound care, 10(6):317-327.

Mufidah N, Sunarsih EN, Dini IRE. 2023. Uji aktivitas penyembuhan luka ekstrak etanol meniran (P. niruri L.) pada kelinci (Oryctolagus cuniculus). J of Res in Pharm, 3(1):65-73.

Munif MR, Safawat SM, Hannan A. 2022. Left lateral flank approach for spaying in cats. Open Veterinary Journal,12(4):540-550.

Mustafa A, Riyadi BD, Kristianto Y, Pudjirahaju A. 2013. Pengaruh pemberian sari ikan gabus (Channa striata) terhadap perbaikan kondisi diabetes pada tikus wistar (Rattus norvegicus) diabetes mellitus. The Indonesian Journal of Public Health, 10(1):56-69.

Porto CRC, Soares LAL, Souza TP, Petrovick PR, Lyra IL, Junior RFA, Langassner SMZ, Ferreira AAA, Guerra GCB. 2013. Anti-inflammatory and antinociceptive activities of P. niruri spray-dried extract. Brazilian Journal of Pharmacognosy, 23(1) : 138-144.

Ramadhanti NA, Sandhika W, Widodo ADW. 2021. The Effect of snakehead fish (Channa striata) extract on inflammation reaction of skin wound tissue in Rattus novergicus Wistar strain. Berkala Ilmu Kesehatan Kulit Dan Kelamin, 33(1):48.

Saffar FJ, Ganabadi S, Fakuraz S. 2011. Response of Channa striatus extract againts monosodium iodoacetate induced ostheoarthritis in rats. J of Anim and Vet Adv, 10(4) : 460.

Siswanto A, Dewi N, Hayatie L. 2016. Effect of haruan (Channa striata) extract on fibroblast cells count in wound healing. Journal of Dentomaxillofacial Science, 1(2):82-87.

Sleep D. 2015. Albumin and its application in drug delivery. Expert Opin Drug Deliv, 12(5):793-812.

Stone EA. 2003. Ovary and Uterus. In Small Animal Surgery. Slatter

D. (Ed.). 3rd ed. WB. Saunders, Philadelphia.

Sugiartanti MF, Oesman D, Elfiah U. 2018. Pengaruh kadar albumin serum terhadap penyembuhan luka pada pasien pascaoperasi laparotomi dan lumbotomi di RSD dr. Soebandi Jember. e-Jurnal Pustaka Kesehatan, 6(3):383-386.

Suryanti Y, Hadisaputro S, Nugraheni SA. 2020. The effect of snakehead fish (Channa striata) extract on blood leukocyte number and cesarean section wound healing. Advances in Social Science, Education and Humanities Research, 443:596-598.

Susibalan BD, Abdullah B, Lazim NM, Kadir AA. 2018. Efficacy of snakehead fish (Channa striatus) in subjects with allergic rhinitis: a randomized controlled trial. Oriental Pharmacy and Experimental Medicine, 18(1):209-215.

Sylvestre A, Wilson J, Hare J. 2002. A comparison of 2 different suture patterns for skin closure of canine ovariohysterectomy. The Canadian Veterinary Journal, 43(9):699–702.

Utariani A, Rahardjo E, Perdanakusuma DS. 2020. Effects of albumin infusion on serum levels of albumin, proinflammatory cytokines (TNF-α, IL-1, and IL-6), CRP, and MMP-8; wound healing in Sprague dawley rats. International Journal of Inflammation, 20 : 1-13.

Vera B, Siswandi R, Soehartono RH. 2023. Ventral median and lateral flank approach for ovariohysterectomy in cats. Jurnal Kedokteran Hewan, 17(1):22-29.

Wathoni N. 2016. Alasan kurkumin efektif mempercepat penyembuhan luka di kulit. Farmasetika, 1(3): 1.

Wulandari T. 2018. Uji efek analgetik temulawak instan (Curcuma xanthorrizha Roxb) pada mencit jantan dengan metode geliat. Jurnal kimia dasar, 7(1): 1-7.

Yuliana B, Sartini, Djide N, Djabir YY. 2022. Wound healing effect of snakehead fish (Channa striata) mucus containing transdermal patch. Journal of Applied Pharmaceutical. Science, 12(7): 171–183.


Article Metrics

Abstract view : 0 times
PDF - 0 times


  • There are currently no refbacks.

Indexed by:


p-ISSN: 1978-225X e-ISSN: 2502-5600 Copyright© 2007-2021