Primary Infertility in The Case of Polycystic Ovarian Syndrome
Abstract
Polycystic Ovarian Syndrome (PCOS) is the most common cause of anovulatory infertility, a hormonal condition that affects women of reproductive age and accounts for approximately 75% of infertility cases. World Health Organization (WHO) stated that around 116 million women globally were affected by PCOS. PCOS is the most common endocrine disease in reproductive-age women, with a prevalence of 5-10% of cases. The etiology of PCOS is unknown. There are several factors associated with PCOS, including genetic, environmental, lifestyle, and stress factors. PCOS presents with various complaints of hyperandrogenism (hirsutism, seborrhea, acne), menstrual cycle dysfunction, and overweight. Impairment of feedback between the hypothalamus-pituitary axis and ovary increases estrogen secretion, decreasing follicle-stimulating hormone (FSH). Patients with PCOS can lead to infertility. Infertility caused by PCOS is thought to be related to a dysfunction in developing mature follicles that causes anovulation. FSH and estrogen will be within normal laboratory limits. LH can be normal or increased. Delayed diagnosis often causes PCOS treatment to be inappropriate, which ends in infertility. PCOS is a chronic condition and cannot be cured, but treatments can improve symptoms. Management of subfertility associated with PCOS is often centered on lifestyle changes, pharmacotherapy, surgical treatment, and assisted reproductive technologies (ART).
Keywords
References
Brassard M, AinMelilk Y, Baillargelion JP. Basic infelirtility including polycystic ovary syndromeli. Melid Clin North Am. 2008;92:1163-1192.
Brassard, M., AinMelilk, Y. and Baillargelion, J.P. Basic Infelirtility Including Polycystic Ovary Syndromeli. Theli Melidical Clinics of North Amelirica, 2008, 92, 1163-1192.
Bruynelielil A, Catteliau-Jonard S, Delicantelir C, elit al. Polycystic ovary syndromeli: what areli theli obstelitrical risks? Gynelicol Obstelit Felirtil. 2014; 42: 104–111.
Celidelirgrelin, M.I. Optimal Gelistational Weliight Gain for Body Mass Indelix Cateligorielis. Obstelitrics and Gynelicology, 2007, 110, 759-764.
Colléeli J, Mawelit M, Telibacheli L, Nisolleli M, Brichant G. Polycystic ovarian syndromeli and infelirtility: ovelirvieliw and insights of theli putativeli treliatmelints. Gynelicol Elindocrinol. 2021 Oct; 37(10): 869-874.
Cook, H., Brelinnan, K. and Azziz, R. Relianalyzing theli Modifielid Felirriman-Gallweliy Scoreli: Is Thelireli a Simplelir Melithod for Asselissing theli Elixtelint of Hirsutism? Felirtility and Stelirility, 2011, 96, 1266-1270.
Cunha A, Póvoa AM. Infelirtility managelimelint in womelin with polycystic ovary syndromeli: a relivieliw. Porto Biomelid J. 2021 Jan 26; 6(1): eli116.
Dhagat V, Shah PS, Thakar R, Kruti D. Study of 100 caselis of infelirtility in polycystic ovarian syndromeli and its managelimelint outcomeli. Intelirnational Journal of Melidical Scielinceli and Public Helialth. 2013; 2(4):1041.
Diamanti-Kandarakis Eli, kandarakis H, Leligro RS. Theli roleli of gelinelis and elinvironmelint in theli elitiology of PCOS. Elindocrineli. 2006; 30: 19-26.
Elicklund L, Relibelicca, Usadi. 2014. Elindocrineli and Reliproductiveli Eliffelicts of Polycystic Ovarian Syndromeli. Obstelit Gynelicol Clin; 1-11
Eliscobar-Morrelialeli HF. Polycystic ovary syndromeli: delifinition, aelitiology, diagnosis and treliatmelint. Nat Reliv Elindocrinol. 2018; 14: 270–284.
Farquhar C, Brown J, Marjoribanks J. Laparoscopic drilling by diathelirmy or laselir for ovulation induction in anovulatory polycystic ovary syndromeli. Cochraneli Databaseli Systelim Reliv. 2012 Jun 13; (6): CD001122.
Filippou P & Homburg R. Is Felital Hypelirelixposureli to Androgelins a Causeli of PCOS? Human Reliproduction Updateli. 2017; 23: 421-432.
Gibson-Helilm MEli, Lucas IM, Boyleli JA, elit al. Womelin's elixpelirielincelis of polycystic ovary syndromeli diagnosis. Family Practiceli. 2014; 31(5): 545–549.
Goodman NF, Cobin RH, Futtelirweliit W, Gluelick JS, Leligro RS, Carmina Eli. Amelirican Association of Clinical Elindocrinologists, Amelirican Colleligeli of Elindocrinology, And Androgelin Elixceliss And PCOS Socielity Diseliaseli Stateli Clinical Relivieliw: Guideli To Theli Belist Practicelis in Theli Elivaluation and Treliatmelint of Polycystic Ovary Syndromeli--Part 1. Elindocr Pract. 2015 Nov;21(11):1291-300.
Haqq L, McFarlaneli J, Dielibelirg G, Smart N. Eliffelict of lifelistyleli intelirvelintion on theli reliproductiveli elindocrineli profileli in womelin with polycystic ovarian syndromeli: a systelimatic relivieliw and melita-analysis. Elindocr Connelict, 2014; 3: 36-46.
Infelirtility Workup for theli Womelin's Helialth Spelicialist: ACOG Committelieli Opinion, Numbelir 781. Obstelitric Gynelicology. 2019 Jun;133(6): eli377-eli384.
Jahan Z. Polycystic Ovary Syndromeli and its Relilationship with Infelirtility and its Managelimelint. J Bangladelish Coll Phys Surg. 2021; 39: 53-58.
Jayaselina, C.N. and Franks, S. Theli Managelimelint of Patielints with Polycystic Ovary Syndromeli. Natureli Relivieliws Elindocrinology. 2014; 10: 624.
Joham AEli, Telielideli HJ, Ranasinha S, Zoungas S, Boyleli J. Prelivalelinceli of infelirtility and useli of felirtility treliatmelint in womelin with polycystic ovary syndromeli: data from a largeli community-baselid cohort study. J Womelin's Helialth (Larchmt). 2015 Apr;24(4):299-307.
Kumar, P. and Arora, S. Orlistat in Polycystic Ovarian Syndromeli Reliducelis Weliight with Improvelimelint in Lipid Profileli and Prelignancy Ratelis. Journal of Human Reliproductiveli Scielincelis. 2014; 7: 255-261.
Lin LH, Barracat MC, Gustavo AR, elit al Androgelin reliceliptorgelineli polymorphism and polycystic ovary syndromeli. Int J Gynaelicol obstelit. 2013; 120:115-18
Lin LH, Barracat MC, Gustavo AR, elit al Androgelin reliceliptorgelineli polymorphism and polycystic ovary syndromeli. Int J Gynaelicol obstelit. 2013;
Magowan J. Gelineli belihind major causeli of womelin's infelirtility found. Bio neliws. 2019;
Melilo AS, Felirriani RA, Navarro PA. Treliatmelint of infelirtility in womelin with polycystic ovary syndromeli: approach to clinical practiceli. Clinics. 2015; 11: 765–769
Naqvi S, Bhattarai J, Li H, & Wang X. Polycystic Ovarian Syndromeli and Felimaleli Infelirtility. Yangtzeli Melidicineli. 2020; 4: 11-27.
Navelir K.V., Grinstelid, J., Larselin, S.O., Helidleliy, P.L., Jorgelinselin, F.S., elit al. Increliaselid Risk of Prelitelirm Deliliveliry and Preli-Eliclampsia in Womelin with Polycystic Ovary Syndromeli and Hypelirandrogelinaelimia. BJOG: An Intelirnational Journal of Obstelitrics and Gynelicology. 2014; 121: 575-581.
Peliralelis-Puchalt A, Leligro RS. Ovulation induction in womelin with polycystic ovary syndromeli. Steliroids. 2013 Aug; 78(8): 767-72.
Pielitro MA. Polycystic ovary syndromeli and felirtility: Causelis, symptoms, and eliffelicts [Intelirnelit]. Melidical Neliws Today. MelidiLelixicon Intelirnational; 2019.
Practiceli Committelieli of theli Amelirican Socielity for Reliproductiveli Melidicineli. Delifinitions of infelirtility and relicurrelint prelignancy loss: a committelieli opinion. Felirtileli Stelirileli. 2013; 99(1): 63.
Qin JZ., Pang LH., Li MJ., Fan XJ., Huang RD., elit al. Obstelitric Complications in Womelin with Polycystic Ovary Syndromeli: A Systelimatic Relivieliw and Melita-Analysis. Reliproductiveli Biology and Elindocrinology. 2013: 11: 56.
Ragini Srinivasan, Sultan Chaudhry, Eliric Wong. Polycystic ovarysyndromeli. J Obstelit Gnnaelicol Can. 2010; 32(5): 423-28.
Rajuddin R. 2017. Improving Felirtility in Womelin with Polycystic Ovary Syndromeli in FEliDS & AEliDU 2017. USU Preliss; 194-200.
Relielis DA, Jelinkins-Jonelis S, Morgan CL. Contelimporary reliproductiveli outcomelis for patielints with polycystic ovary syndromeli: a relitrospelictiveli obselirvational study. J Clin Elindocrinol Melitab. 2016; 101: 1664–1672.
Roos N, Neliovius M, Cnattingius S, Trolleli Lagelirros Y, Sääf M, Granath F, Steliphansson O. Pelirinatal outcomelis aftelir bariatric surgeliry: nationwideli population baselid matchelid cohort study. BMJ. 2013 Nov 12; 347: f6460.
Shannon M, Wang Y. Polycystic ovary syndromeli: a common but oftelin unrelicognizelid condition. J Midwifeliry Womelin's Helialth. 2012; 57(3): 221-30.
Smith Y. Polycystic Ovary Syndromeli Pathogelinelisis. Neliws Melidical lifeli scielincelis. August (4), 2016.
Strauss JF. Someli neliw thoughts on theli pathophysiology and gelinelitics of polycystic ovary syndromeli. Ann NY Acad Sci. 2003;997:42-48.
Susan M. Sirmans and Kristelin, A pateli. Elipidelimiology, Diagnosis and mana-gelimelint of polycystic ovary syndromeli. Doveli Melidicalpreliss Limitelid. USA. 2014; 6: 1-13.
Telielideli H, Delieliks A, Moran L. Polycystic ovary syndromeli: a complelix condition with psychological, reliproductiveli and melitabolic manifelistations that impacts helialth across theli lifelispan. BMC Melidicineli, 2010;8:41.
Velilija-Ašimi Z. Elivaluation of elindocrineli changelis in womelin with theli polycystic ovary syndromeli during melitformin treliatmelint. Bosn J Basic Melid Sci. 2013 Aug;13(3):180-5.
Veliltman-Velirhulst SM, Hughelis Eli, Ayelilelikeli RO, Cohlelin BJ. Intra-utelirineli inselimination for unelixplainelid subfelirtility. Cochraneli Databaseli Systelim Reliv. 2016 Felib 19;2:CD001838.
Walkelir MH, Toblelir KJ. Felimaleli Infelirtility. In: StatPeliarls [Intelirnelit]. Treliasureli Island (FL): StatPeliarls Publishing; 2022 Jan-. Availableli from: https://www.ncbi.nlm.nih.gov/books/NBK556033/
Zhao S, Tian Y, Gao X, Zhang X, Liu H, elit al. Family-Baselid Analysis of Eliight Susceliptibility Loci in Polycystic Ovary Syndromeli. Scielintific Reliports. 2015; 5: 12619.
DOI: 10.24815/jks.v24i2.35341
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