Changes in total nasal symptoms score and quality of life after supplementation of Habbatussauda (Nigella sativa) in persistent Allergic Rhinitis
Abstract
Introduction: Allergic Rhinitis (AR) is health problem that can influence a patient’s quality of life, affecting them through various nasal symptoms. Habbatussauda (Nigella sativa) can alleviate the nasal symptoms due to its component Thymoquinone, which acts as a bioactive substance possessing anti-inflammatory, anti-oxidant, and anti-microorganism properties.
Objective: This study aims to evaluate the change in total nasal symptom scores and the enhanced quality of life in persistent AR patients after supplementation with habbatussauda.
Methods: Experimental study with parallel design was conducted in two subject groups, group H (habbatussauda) and group P (Placebo). Both groups were given standard therapy. Group H was given additional supplementation of habatussauda 2 gr for 28 days. Nasal symptoms score were measured using Total Nasal Symptoms Score (TNSS) and quality of life was measured using Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ). Data were analyzed using Mann-Whitney U test.
Results: A total of 42 AR patients were involved which are divided into 21 subjects in each group. An average age of 31 years in the habatussauda group and 34 years in the control group which were dominated by men. In group H, the mean change in TNSS was 3.45 and RQLQ score was 17.67. Meanwhile in group P, the mean change in TNSS was 1 and RQLQ score was 8. From these results, the change in TNSS in group H was better than group P(p=0.001), likewise the RQLQ score showed a better change in group H(p=0.001).
Conclusion: Supplementation of habbatussauda for 28 days can decrease the degree of TNSS and increase quality life on AR patients.
Keywords
References
An S-Y, Choi HG, Kim SW, Park B, Lee JS, Jang JH, et al. Analysis of various risk factors predisposing subjects to allergic rhinitis. Asian Pac J Allergy Immunol. 2015;33(2):143-51.
Ansari MA, Ahmed SP, Haider S, Ansari NL. Nigella sativa: A non-conventional herbal option for the management of seasonal allergic rhinitis. Pak J Pharmacol. 2006;23(2):5-31.
Bernstein DI, Schwartz G, Bernstein JA. Allergic rhinitis: Mechanisms and treatment. Immunology and Allergy Clinics. 2016;36(2):261-78.
Bousquet PJ, Combescure CF, Neukirch F, Klossek JM, Merchin H, dayres JP, et al. Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines. 2015.
Carr TF, Saltoun CA. Skin testing in allergy. Allergy and Asthma Proceedings. 2012;42-52.
Chawla D, Singh A, Gupta M, Matreja PS, Khanna PM. To compare the safety, efficacy and quality of life in patients with allergic rhinitis treated with levocetirizine and desloratadine. J Clin Cell Immunol. 2014;5(216):2.
Chong SN, Chew FT. Epidemiology of allergic rhinitis and associated risk factors in Asia. World Allergy Organization Journal. 2018;11:17.
Gholamnezhad Z, Shakeri F, Saadat S, Ghorani V, Boskabady MH. Clinical and experimental effects of Nigella sativa and its constituents on respiratory and allergic disorders. Avicenna journal of phytomedicine. 2019;9(3):195.
Hoang MP, Chitsuthipakorn W, Snidvongs K. Herbal medicines for allergic rhinitis: a systematic review and meta-analysis. Current Allergy and Asthma Reports. 2021;21(4):1-12.
Hutten CP. The occasional allergy skin test. Canadian Journal of Rural Medicine. 2019;24(3):92.
Juniper EF, Guyatt GH, Griffith LE, Ferrie PJ. Interpretation of rhinoconjunctivitis quality of life questionnaire data. Journal of allergy and clinical immunology. 1996;98(4):843-5.
Kakli HA, Riley TD. Allergic rhinitis. Primary Care: Clinics in Office Practice. 2016;43(3):465-75.
Kalmarzi RN, Khazaei Z, Shahsavar J, Gharibi F, Tavakol M, et al. The impact of allergic rhinitis on quality of life: a study in western Iran. Biomedical research and therapy. 2017;4(9):1629-37.
Koç A, Güven N, Öztürk SB, Dedeoglu BD, Feyza H, Buyukhelvacigil RB, et al. Therapeutic trials of Nigella sativa. Journal of Pharmacy and Pharmacology. 2019;7:564-77.
Linneberg A, Petersen KD, Hahn-Pedersen J, Hammerby E, Hansen S, Boxall N. Burden of allergic respiratory disease: a systematic review. Clinical and Molecular Allergy. 2016;14(1):1-14.
Meltzer EO. Allergic rhinitis: burden of illness, quality of life, comorbidities, and control. Immunology and Allergy Clinics. 2016;36(2):235-48.
Naafs MA. The burden of allergic rhinitis: a mini-review. Global J Otolaryngol. 2018;13(1).
Nikakhlagh S, Rahim F, Aryani FHN, Syohpoush A, Brougerdnya MG, Saki N. Herbal treatment of allergic rhinitis: the use of Nigella sativa. American J of otolaryngology. 2011;32(5):402-7.
Passali D, Cingi C, Staffa P, Passali F, Muluk NB, Bellusi ML. The international study of the allergic rhinitis survey: outcomes from 4 geographical regions. Asia Pacific Allergy. 2018;8(1):1-12.
Rapiejko P, Jurkiewicz D, Pietruszewska W, Jurkiewicz Z, Woron J, Lipiec A, et al. Treatment strategy of allergic rhinitis in the face of modern world threats. Otolaryngologia Polska. 2018;72:1-12.
Saadat S, Aslani MR, Ghorani V, Keyhanmanesh R, Boskabady MH. The effects of Nigella sativa on respiratory, allergic and immunologic disorders, evidence from experimental and clinical studies, a comprehensive and updated review. Phytotherapy Research. 2021;35(6):2968-96.
Sarumpaet RD. Perbandingan efektifitas loratadine dan chlorpheniramine maleat terhadap kualitas hidup penderita rinitis alergi. Solo: Universitas Diponogoro;2001.4(6):421-430
Sherwood L. Human physiology. In Crosby L, Editors. Virginia: Cengage; 2018;p.103-126.
Soegiarto G, Abdullah MS, Damayanti LA, Suseno A, Effendi C. The prevalence of allergic diseases in school children of metropolitan city in Indonesia shows a similar pattern to that of developed countries. Asia Pacific Allergy. 2019;9(2).
Utomo BSR, Hatta M, Sirait RH, Pratiwi S, Massi MN. The role of cytokine interleukin-2, transcription factor of foxp3 in the immunological regulation of allergic rhinitis. International Journal of Otolaryngology and Head & Neck Surgery. 2018;7(1):7-19.
Yamprassert R, Chanvimalueng W, Mukkasombut N. Ginger extract versus Loratadine in the treatment of allergic rhinitis. BMC Coplementary Medicine and Therapies. 2020;20:119.
Zhang J-X, Wang W-Y. Clinical efficacy of tuomin zhiti decoction in allergic rhinitis. Evidence-Based Complementary and Alternative Medicine. 2022;22:2-6
DOI: 10.24815/jks.v24i1.36016
Refbacks
- There are currently no refbacks.