The antinematicidal activity of vitamin E and its derivatives on Sterinernema feltieae

Abstract

Vitamin E is found naturally in some foods, and also available as a dietary supplement. "Vitamin E" is the fat-soluble compounds with distinctive antioxidant activities. The vitamin E acts as an antioxidant, which protects cell membranes. Sterinernema feltieae was selected as a test organism is because this organism is a complex organism and can be used as a model for whole organisms. The objective of this study is to evaluate the activity of vitamin E and its derivatives on Sterinernema feltieae. The results showed that the derivative of vitamin E (C₃₇H₅₅NO₃) was most active against S. feltiae with the LD₅₀ value was 207.77 μM, followed by vitamin E (C₂₉H₅₀O₂) with the LD₅₀ value was 209.09 μM. These results indicated that derivative of vitamin E (C₃₇H₅₅NO₃) exerts more potent toxicity than vitamin E against Sterinernema feltieae.