Montmorillonite-Chitosan as a Biocomposite Encapsulation for Ibuprofen in Drug Release
Abstract
Ibuprofen is a type of anti-inflammatory drug. However, its use faces challenges in the medical field due to its rapid degradation, low bioavailability, limited solubility, and high permeability. One approach to address these issues is the encapsulation of ibuprofen by coating it with Montmorillonite (MMT) and Chitosan (CS) to control the released dosages of Ibuprofen. MMT and CS were used to coat ibuprofen using four methods. These methods were compared through dispersing MMT in water, mixing with chitosan, and combining ibuprofen under different conditions. Subsequently, tests were conducted on ibuprofen coated with MMT-CS, including morphology, efficiency, and release profile. The most effective method for controlling ibuprofen release was shown in the third method, where MMT-CS was first modified, and then ibuprofen was added to the modified MMT-CS. This method showed the highest encapsulation efficiency of 61.51%, the best release profile with 21.59% ibuprofen release within 90 minutes, and the most uniform encapsulation morphology. These studies indicated that the MMT-CS biocomposite effectively improves ibuprofen release efficiency, potentially enhancing therapeutic outcomes while reducing side effects of ibuprofen.
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Macedo, L.D.O.; Barbosa, E. J.; Löbenberg, R.; Bou-Chacra, N.A., Anti-inflammatory drug nanocrystals: state of art and regulatory perspective. Eur. J. Pharm. Sci., 2020, 158 105654.
Zoubek, M.E.; Lucena, M. I.; Andrade R.J., Stephens C. Systematic review: ibuprofen-induced liver injury. Aliment Pharmacol Ther., 2020, 51 603–611.
Chaffey, L.; Roberti, A.; Greaves, D.R., Drug repurposing in cardiovascular inflammation: Successes, failures, and future opportunities. Front. Pharmacol., 2022, 13 1046406.
Irvine, J.; Afrose, A.; Islam, N., Formulation and delivery strategies of ibuprofen: Challenges and opportunities. Drug Dev. Ind. Pharm., 2018, 44 173–183.
Pereira, E.D.; Thomas, S.; Gomes, F.S.J.; Cardoso, J.S.; Filho, S.T.; Costa, V.C.; Maranhão, F.S.; Ricardo, N.B.L.; Carvalho, F.V.; Aboelkheir, M.G., Study of controlled release of ibuprofen magnetic nanocomposites. Journal of Molecular Structure. 2021, 1232 130067.
Kucharska, E.; Berin, O.; Nowak, A.; Kucharski, L.; Anna, M.S.; Paula, O.R., Ibuprofen Formulations: Permeability and Biodegradability Comparison Depending on the Type of Formulation. Processes. 2024, 12 1236.
Javanbakht, S.; Nezhad-Mokhtari, P.; Shaabani, A.; Arsalani, N.; Ghorbani, M., Incorporating Cu-based metal-organic framework/drug nanohybrids into gelatin microsphere for ibuprofen oral delivery. Mater. Sci. Eng. 2019, 96 302−309.
Ibrahim, S.M.; Bin Jumah, M.N.; Othman, S.I.; Alruhaimi, R.S.; Al-Khalawi, N.; Salama, Y.F.; Abukhadra, M.R., Synthesis of chitosan/diatomite composite as an advanced delivery system for ibuprofen drug; equilibrium studies and the release profile. Acs Omega. 2021, 20 13406-13416.
Han, J.; Xiao, B.; Kim, P.L.; Mangwandi, C., Enhancement of the Solubility of BS Class II Drugs with MOF and MOF/GO Composite Materials: Case Studies of Felodipine, Ketoprofen and Ibuprofen. Materials. 2023, 16 1554.
Chakraborty, A.; Nandi, R.; Kumar, D.; Acharya, H., Investigation on the Drug Release Efficacy of the Ibuprofen-Loaded ZIF-8/Fe3O4 NPs Nanocarrier. ACS Omega. 2024, 9 32418−32428.
Carmo, C.C.; Brito, M.; Oliveira, J.P.; Marques, A.; Ferreira,.I.; Baptista, A.C., Cellulose Acetate and Polycaprolactone Fibre Coatings on Medical-Grade Metal Substrates for Controlled Drug Release. Polymers. 2024, 16 2006.
Abukhadra, M.R.; Refay, N.M.; El-Sherbeeny, A.M.; Mostafa, A.M.; Elmeligy, M.A., Facile synthesis of bentonite/biopolymer composites as low-cost carriers for 5-fluorouracil drug; equilibrium studies and pharmacokinetic behavior. Int. J. Biol. Macromol. 2019, 141 721−731.
Rodrigues, C.; Muneron de Mello, J.M.; Dalcanton, F.; Macuvele, D.L.P.; Padoin, N.; Fiori, M.A.; Soares, C.; Riella, H.G., Mechanical, Thermal and Antimicrobial Properties of Chitosan Based Nanocomposite with Potential Applications for Food Packaging. J. Polym. Env. 2020, 28 1216-1236.
Parhi, R.; Jena, G.K.,Montmorillonite-Chitosan based Nano-Composites and Applications. Adv. App. of Micro and Nano Clay. 2022, 125 49-86.
Servatan, M.; Zarrintaj, P.; Mahmodi, G.; Kim, S. J.; Ganjali, M. R.; Saeb, M. R.; Mozafari, M., Zeolites in drug delivery: Progress, challenges and opportunities. Drug Discovery Today. 2020, 25 642−656.
Thambiliyagodage, C.; Jayanetti, M.; Mendis, A.; Ekanayake, G.; Liyanaarachchi, H.; Vigneswaran, S., Recent Advances in Chitosan-Based Applications: A Review. Materials. 2023, 16 2073
Ali, A.; Ahmed, S., A review on chitosan and its nanocomposites in drug delivery. Int. J. Biol. Macromol. 2018, 109 273–286.
Sugita, P.; Achmadi, S.S.; Yundhana, Y., Perilaku Disolusi Ketoprofen Tersalut Gel Kitosan-Karboksimetilselulosa (CMC). Jurnal Natur Indonesia. 2010, 13 21-26
Abdeen, R.; Salahuddin, N., Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen. Journal of Chemistry. 2013
Işıklan, N.; Kucukbalcı, G., Synthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide/acrylic acid) for drug delivery. Polym Bull. 2015, 73 1321–1342
Wahyuni, S.; Selvina, R.; Fauziyah, R.; Prakoso, H.T.; Priyono, S., Optimization of Temperature and Time of Chitin Deacetylation in Maggot Cells (Hermetia ilucens) to Produce Chitosan. Jurnal Ilmu Pertanian Indonesia (JIPI). 2020, 25 373-381.
Jacob, S.; Nair, A.B.; Shah, J., Emerging role of nanosuspensions in drug delivery systems. Biomaterials Research. 2020, 3 24
Olivera, S.; Muralidhara, H.B.; Venkatesh, K.; Guna, V.K.; Gopalakrishna, K.; Kumar, K.Y., Potential applications of cellulose and chitosan nanoparticles/composites in wastewater treatment: A review. Carbohyd. Polym. 2016, 153 600-618.
Luo, C.; Yang, Q.; Lin, X.; Chenze, Q.; Guohua, L., Preparation and drug release property of tanshinone IIA loaded chitosan-montmorillonite microspheres. International Journal of Biological Macromolecules. 2019, 125 721-729
Azeem, B.; Sadiq-ur-Rehman.; Tasleem, A.; Kalsoom, A.; Farooq, M.; Imran, S.M., Alginate‑chitosan/MWCNTs nanocomposite: a novel approach for sustained release of Ibuprofen. Journal of Polymer Research. 2020, 27 363
Lerner, D.A.; Begu, S.; Aubert-Pouessel, A.; Polexe, R.; Devoisselle, J.M.; Azais, T.; Tichit, D., Synthesis and Properties of New Multilayer Chitosan@layered Double Hydroxide/Drug Loaded Phospholipid Bilayer Nanocomposite Bio-Hybrids. Materials. 2020, 13 3565
Darder, M.; Colilla, M.; Ruiz-Hitzky, E., Biopolymer−clay nanocomposites based on chitosan intercalated in montmorillonite. Chem. Mater. 2003, 15 3774–3780.
Cheikh, D.; Fatima, G.V.; Majdoub, H.; Viseras, C.; Zayani, M.B; Chitosan/beidellite nanocomposite as diclofenac carrier. International Journal of Biological Macromolecules. 2019, 126 44–53.
Jiang, Y.; Wang, Z.; Cao, K.; Xia, L.; Wei, D.; Zhang, Y., Montmorillonite-Sodium Alginate Oral Colon-Targeting Microcapsule Design for WGX-50 Encapsulation and Controlled Release in Gastro-Intestinal Tract. J. Funct. Biomater. 2024, 15 3.
DOI: https://doi.org/10.24815/jocarbazon.v2i2.42149
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