The efficacy of scaling root planing to inflammation biomarker of periodontitis patients with atherosclerosis

Abstract

ABSTRACT Periodontitis is a disease of surrounding dental tissue with a prevalence of 74.1% in
Indonesia. Many studies show periodontitis plays a role in the progression of atherosclerosis. The
relationship between these two conditions shows that scaling root planing intervention can reduce the
risk of atherosclerosis. This study aimed to know the efficacy of scaling root planing on changes in
inflammatory biomarkers in periodontitis patients with atherosclerosis. This systematic literature review
was conducted using the Rapid Review method that refers to the Preferred Reporting Items for
Systematic Review and Meta-Analysis (PRISMA) guidelines. Electronic searches were carried out from 4
electronic databases, including the National Library of Medicine (Medline / PubMed), The Cochrane
Library, EbscoHOST, and SAGE Journal. Inclusion and exclusion criteria selected 6 RCT articles to be
analyzed qualitatively. Within 2 to 6 months, research in 6 RCT articles showed the results in
significantly reducing CRP levels as the main biomarkers of atherosclerosis after scaling root planing
intervention. Other biomarkers that were also assessed are cytokines levels, lipid profile components,
WBC, and fibrinogen. Overall results showed a positive effect of scaling root planing intervention in
reducing the inflammatory biomarker levels of atherosclerosis in periodontitis patients with
atherosclerosis. The treatment of scaling root planing is considered effective in reducing the
inflammatory biomarker levels of atherosclerosis in periodontitis patients with atherosclerosis to reduce
the level of risk.
KEYWORDS: scaling root planing, inflammatory biomarker, atherosclerosis