The Effect of Administration of Lycopene on Interleukin 8 Levels and Hospitalization Time of Patients with Chronic Obstructive Pulmonary Disease Exacerbations
Abstract
Background: Exacerbated chronic obstructive pulmonary disease is an acute condition, characterized by persistent air flow limitations, related to the excessive chronic inflammatory response in the airways and lung parenchyma caused by exposure to harmful gases or particles. Increased airway inflammation during exacerbations leads to increased levels of IL-8 and the risk of hospitalization. Lycopene is a carotenoid which has a positive effect on the respiratory system. The purpose of this study was to determine the effect of administration lycopene to IL-8 levels and hospitalization time of patients with COPD disease exacerbations.
Methods: The experimental test with pretest and posttest design for 30 patients with COPD exacerbations in Dr. Moewardi Surakarta Hospital and Dr. Soehadi Prijonegoro Sragen Hospital was conducted from February to March 2018. Samples were taken by consecutive sampling divided into two groups including the treatment group receiving standard therapy and lycopene 1x10 mg / day during treatment and the control group only receiving standard therapy. IL-8 levels and hospitalization time of patients with COPD disease exacerbations were measured.
Results: There were significant differences between the treatment group compared to the control group for a decrease in IL-8 (p = 0.029) and a decrease in hospitalization time (p = 0,000).
Conclusion: The administration of lycopene 1x10 mg / day significantly reduce IL-8 levels and hospitalization time of patient with COPD exacerbations.
Keywords
References
References
Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, editors. Fitzpatrick’s dermatology in general medicine. 9th ed; vol.1. New York: McGraw-Hill; 2012.
Goyal A, Balai M, Mittal A, Khare AK, Gupta LK. Pattern of geriatric dermatoses at a Tertiary Care Teaching Hospital of South Rajasthan, India. Our Dermatol Online. 2017;8(3):237-241.
Damayanti. Penuaan kulit dan perawatan kulit dasar pada usia lanjut. Periodical of dermatology and venerology. 2017;9 (1): 73-80.
Kementerian Kesehatan Republik Indonesia. Data dan informasi Profil Kesehatan Indonesia 2017. 2017
Dedianto H, Yunita H, Hendrawan. Karakteristik Penyakit Kulit pada Geriatri di Poliklinik Kulit dan Kelamin RSUD Provinsi Nusa Tenggara Barat Periode 2012-214. Jurnal Kedokteran Unram. 2017
AAIA Nyndia Sari, IGAM Sri Widyastuti, Fransiska Sylvana K, Made Swastika Adiguna, Luh Mas Rusyati. Profil Penyakit Kulit pada Geriatri di RSUP Sanglah, Denpasar Tahun 2009-2011. Dalam : Indah Julianto, Prasetyadi Mawardi dkk ed. Kumpulan Makalah Lengkap PIT XII Perdoski. Surakarta: ITA. 2012;p. 42–48.
Mira Rahmanita R, Sri Agustina, Endra Yustin, Nugrohoaji Darmawan, Prasetyadi Mawardi. Penelitian retrospektif: Pola penyakit kulit pada geriatri di RSUD Dr. Moewardi Surakarta. Dalam : Indah Julianto, Prasetyadi Mawardi dkk ed. Kumpulan Makalah Lengkap PIT XII Perdoski. Surakarta: ITA. 2012;p. 829–831
Sukmawati TT, Mahmud G, Peter JH, Ricky D. Basal Cell Carcinoma Arises from Interfollicular Layer of Epidermis. Hindawi Journal of Oncology. Volume 2018
Zahruddin A, Damayanti. Penuaan Kulit: Patofisiologi dan Manifestasi Klinis. Periodical of Dermatology and Venereology Vol. 3. 2018
Rika L, Hendra TS. Vitiligo. Jurnal Kedokteran Unila Volume 5. 2015
Zygawindi N, Syafei H. Diagnosis dan Tatalaksana Pemfigoid Bulosa : Tinjauan Kasus pada Pasien Geriatri. Majority Volume 6. 2017
DOI: 10.24815/jks.v19i1.17404
Refbacks
- There are currently no refbacks.