Hubungan kadar testosteron total serum serum dengan kadar free t4 dan gejala klinispada wanita dengan penyakit graves di RSUP DR. Mohammad Hoesin Palembang
Abstract
Pendahuluan. Penyakit Graves merupakan penyakit autoimun pada kelenjar tiroid yang menyebabkan kondisi hipermetabolik ditandai dengan peningkatan kadar hormon T3 dan T4 penurunan kadar hormon TSH. Insidensi penyakit Graves di dunia adalah 20-50 kasus/100.000 penduduk tiap tahunnya Hormon tiroid mempengaruhi fungsi neurotransmiter secara langsung, metabolisme jaringan, proses oksidasi jaringan, proses pertumbuhan, sintesis protein, termogenesis jaringan, laju metabolik basal. Pada hipertiroid kadar testosteron meningkat, terutama testosteron total karena sex hormones binding globulin (SHBG) yang meningkat. Tujuan penelitian ini untuk mengetahui korelasi kadar testosterone total serum dengan kadar ft4 serum dan gejala klinis pada pasien penyakit Graves yang berobat di RSMH Palembang.
Metode. Penelitian ini adalah uji korelasi untuk melihat hubungan korelasi testosterone total serum kadar serum dengan kadar fT4 dan gejala klinis pada pasien penyakit Graves yang berobat di RSMH Palembang dari Februari 2021 hingga April 2021. Jumlah subjek penelitian sebanyak 23, merupakan pasien penyakit hipertiroid Graves yang berobat di RSMH Palembang. Semua subjek dilakukan pemeriksaan kadar fT4, TSH, indeks Wayne, dan kadar testosterone total.
Hasil. Terdapat 23 orang subjek penelitian dengan median umur 30.9 tahun.Median fT4 sebesar 1.10 ng/Ldengan rentang 0.75 ng/L - 4.81 ng/L. Terdapat 3 kelompok berdasarkan fT4 yaitu kelompok rendah, normal, dan tinggi dengan batasan operasional kadar fT4 normal sebesar 0.7 – 1.48 ng/L.Nilai median indeks Wayne sebesar 20 dengan rentang 17-33. Tidak terdapat subjek dalam kategori eutiroid. Terdapat 11 (47.8%) subjek dengan kategori meragukan (rentang indeks 11-19), 12 (52.2% ) subjek hipertiroid (indeks >19). Nilai rerata kadar testosteron sebesar 34.83 µIU/L.Terdapat korelasi yang bermakna antara testosterone total dengan fT4 (p=0,00, r=0,677), testosteron total dengan indeks Wayne (p=0,00, r= 0,799).
Simpulan.Terdapat hubungan yang bermakna antara kadar testosterone total dengan ft4 dan gejala klinis berdasar indeks Wayne
Keywords
References
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DOI: 10.24815/jks.v22i3.21066
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