Interaksi obat potensial pada pasien usia lanjut
Abstract
Interaksi obat beresiko terjadi pada kelompok usia lanjut karena penggunaan jumlah obat yang banyak (polifarmasi). Resiko interaksi obat ini dapat meningkat karena perubahan anatomi dan fisiologi tubuh yang menyebabkan penurunan fungsi dari organ yang terlibat dalam proses absorpsi, metabolisme, distribusi dan ekskresi obat. Artikel ini memaparkan beberapa interaksi obat potensial akibat penggunaan lebih dari satu obat pada saat yang bersamaan. Interaksi obat tersebut meliput penggunaan warfarin, ACE-inhibitor dan Digoksin.
Keywords
References
Abbas, S., Ihle, P., Harder, S., & Schubert, I. (2015). Risk of hyperkalemia and combined use of spironolactone and long‐term ACE inhibitor/angiotensin receptor blocker therapy in heart failure using real‐life data: a population‐and insurance‐based cohort. Pharmacoepidemiology and Drug Safety, 24(4), 406-413.
Al-Khadra, A. S., Salem, D. N., Rand, W. M., Udelson, J. E., Smith, J. J., & Konstam, M. A. (1998). Antiplatelet agents and survival: a cohort analysis from the Studies of Left Ventricular Dysfunction (SOLVD) trial. Journal of the American College of Cardiology, 31(2), 419-425.
Ament, P. W., Bertolino, J. G., & Liszewski, J. L. (2000). Clinically significant drug interactions. American family physician, 61(6), 1745-1754.
Choi, K. H., Kim, A. J., Son, I. J., Kim, K.-H., Kim, K.-B., Ahn, H., & Lee, E. B. (2010). Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting. Journal of Korean medical science, 25(3), 337-341.
Delafuente, J. C. (2003). Understanding and preventing drug interactions in elderly patients. Critical reviews in oncology/hematology, 48(2), 133-143.
Delaney, J. A., Opatrny, L., Brophy, J. M., & Suissa, S. (2007). Drug–drug interactions between antithrombotic medications and the risk of gastrointestinal bleeding. Cmaj, 177(4), 347-351.
Egger, S. S., Bravo, A. E. R., Hess, L., Schlienger, R. G., & Krähenbühl, S. (2007). Age-related differences in the prevalence of potential drug-drug interactions in ambulatory dyslipidaemic patients treated with statins. Drugs & aging, 24(5), 429-440.
Hayes, B. D., Klein-Schwartz, W., & Barrueto Jr, F. (2007). Polypharmacy and the geriatric patient. Clinics in geriatric medicine, 23(2), 371-390.
Ho, L. L., & Brighton, T. (2002). Warfarin, antiplatelet drugs and their interactions. Australian Prescriber, 25(4), 81-84.
Juurlink, D. N., Mamdani, M., Kopp, A., Laupacis, A., & Redelmeier, D. A. (2003). Drug-drug interactions among elderly patients hospitalized for drug toxicity. Jama, 289(13), 1652-1658.
Kane, R., Ouslander, J., Abrass, I., & Resnick, B. (2009). Incontinence. Essentials of Clinical Geriatrics, 6th edition. New York: McGraw Hill, 213-263.
Lesko, L. (1989). Pharmacokinetic drug interactions with amiodarone. Clinical pharmacokinetics, 17(2), 130-140.
Liu, A., & Stumpo, C. (2007). Warfarin-drug interactions among older adults. Geriatrics and Aging, 10(10), 643.
Mallet, L., Spinewine, A., & Huang, A. (2007). The challenge of managing drug interactions in elderly people. The Lancet, 370(9582), 185-191.
Matchar, D. B., McCrory, D. C., Orlando, L. A., Patel, M. R., Patel, U. D., Patwardhan, M. B., . . . Gray, R. N. (2008). Systematic review: comparative effectiveness of angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers for treating essential hypertension. Annals of internal medicine, 148(1), 16-29.
Midlöv, P., Eriksson, T., & Kragh, A. (2009). Drug-related Problems in the Elderly: Springer Science & Business Media.
Moysey, J., Jaggarao, N., Grundy, E., & Chamberlain, D. (1981). Amiodarone increases plasma digoxin concentrations. British Medical Journal (Clinical research ed.), 282(6260), 272.
Nguyen, K. N., Aursnes, I., & Kjekshus, J. (1997). Interaction between enalapril and aspirin on mortality after acute myocardial infarction: subgroup analysis of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II). The American journal of cardiology, 79(2), 115-119.
Park, M. H. (2003). Should Aspirin Be Used With Angiotensin‐Converting Enzyme Inhibitors in Patients With Chronic Heart Failure? Congestive Heart Failure, 9(4), 206-211.
Pedone, C., Cecchi, E., Matucci, R., Pahor, M., Carosella, L., Bernabei, R., & Mugelli, A. (2005). Does aspirin attenuate the beneficial effect of ACE inhibitors in elderly people with heart failure? Drugs & aging, 22(7), 605-614.
That, S. D. (2004). Drug interactions with digoxin: the role of P-glycoprotein. Pharmacy times45.
Wrenger, E., Müller, R., Moesenthin, M., Welte, T., Frölich, J. C., & Neumann, K. H. (2003). Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases. Bmj, 327(7407), 147-149.
DOI: 10.24815/jks.v21i1.21272
Refbacks
- There are currently no refbacks.