Leptospirosis presenting with acute renal failure, thrombocytopenia, and hyperbilirubinemia
Abstract
Leptospirosis is a spirochaetal zoonotic disease associated with a broad spectrum of clinical manifestations from asymptomatic to multi-organ failure and death. Acute liver and renal involvement in severe forms of leptospirosis is known as Weil’s disease. Gold-standard serology test results may delay treatment and can cause rapid clinical deterioration. We present a patient with severe leptospirosis that was treated with empiric treatment without confirming the gold-standard confirmatory serology tests.
References
Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, et al. Global Morbidity and Mortality of Leptospirosis: A Systematic Review. PLoS Negl Trop Dis. 2015;9(9):0–1.
Garba B, Bahaman AR, Bejo SK, Zakaria Z, Mutalib AR, Bande F. Major epidemiological factors associated with leptospirosis in Malaysia. Acta Trop [Internet]. 2018;178(November 2017):242–7. Available from: https://doi.org/10.1016/j.actatropica.2017.12.010
Maas M, De Vries A, Reusken C, Buijs J, Goris M, Hartskeerl R, et al. Prevalence of Leptospira spp. and Seoul hantavirus in brown rats (Rattus norvegicus) in four regions in the Netherlands, 2011-2015. Infect Ecol Epidemiol [Internet]. 2018;8(1):2011–5. Available from: https://doi.org/10.1080/20008686.2018.1490135
Cagliero J, Villanueva SYAM, Matsui M. Leptospirosis pathophysiology: Into the storm of cytokines. Front Cell Infect Microbiol. 2018;8(JUN):1–8.
Maroun E, Kushawaha A, El-Charabaty E, Mobarakai N, El-Sayegh S. Fulminant leptospirosis (Weil’s disease) in an urban setting as an overlooked cause of multiorgan failure: A case report. J Med Case Rep. 2011;5:5–8.
Daher EF, Silva Junior GB, Silveira CO, Falcão FS, Alves MP, Mota JAAA, et al. Factors associated with thrombocytopenia in severe leptospirosis (Weil’s disease). Clinics. 2014;69(2):106–10.
Soo ZMP, Khan NA, Siddiqui R. Leptospirosis: Increasing importance in developing countries. Acta Trop. 2020;201(August 2019).
Picardeau M. Diagnosis and epidemiology of leptospirosis. Med Mal Infect. 2013;43(1):1–9.
Seguro AC, Andrade L. Pathophysiology of leptospirosis. Shock. 2013;39(7 SUPPL.1):17–23.
Brett-Major DM, Coldren R. Antibiotics for leptospirosis. Cochrane Database Syst Rev. 2012;(2).
Naing C, Reid SA, Aung K. Comparing antibiotic treatment for leptospirosis using network meta-analysis: A tutorial. BMC Infect Dis [Internet]. 2017;17(1):1–9. Available from: http://dx.doi.org/10.1186/s12879-016-2145-3
Cosson JF, Picardeau M, Mielcarek M, Tatard C, Chaval Y, Suputtamongkol Y, et al. Epidemiology of Leptospira Transmitted by Rodents in Southeast Asia. PLoS Negl Trop Dis. 2014;8(6).
Budihal SV, Perwez K. Leptospirosis diagnosis: Competancy of various laboratory tests. J Clin Diagnostic Res. 2014;8(1):199–202.
Gasem MH, Hadi U, Alisjahbana B, Tjitra E, Hapsari MMDEAH, Lestari ES, et al. Leptospirosis in Indonesia: Diagnostic challenges associated with atypical clinical manifestations and limited laboratory capacity. BMC Infect Dis. 2020;20(1):1–11.
Jose LR, Sumana MN. Utilization of Faine ’ s Criteria for the Diagnosis of Leptospirosis. IOSR J Dent Med Sci. 2016;15(3):28–30.
Pothuri P, Ahuja K, Kumar V, Lal S, Tumarinson T, Mahmood K. Leptospirosis presenting with rapidly progressing acute renal failure and conjugated hyperbilirubinemia: A case report. Am J Case Rep. 2016;17:567–9.
DOI: 10.24815/jks.v22i1.23286
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