Quantitative Evaluation of Antibiotic Usage in ICU Ward at West Nusa Tenggara Province Hospital in 2018

Oci Qonita Londo Woro, Dewi Suryani, Ni Made Amelia Ratnata Dewi

Abstract


The number of antibiotic resistances in hospitals and healthcare is increasing. The resistances prevalence rate in Intensive Care Unit (ICU) room is 11,6-22,5%. This research aim is to evaluate the usage of antibiotics of patients in ICU at West Nusa Tenggara Provincial Hospital in 2018. This research is observational and applies a cross-sectional design that collects data retrospectively, with the total number of samples are 64 patients who met inclusion criteria and employs DDD/100 patient-days system analysis method. The result of this study shows, among 64 patients; there are 37 male and 27 female patients; 48 adult and 16 elderly patients. Among 11 groups of cases, the highest case is neurosurgery with 30 patients. The total length of stay (LOS) of all patients is 621 days, where the range of LOS is 1-69 days, and the median value is 6 days. According to the calculation, there are 17 types of antibiotics used in the ICU room of West Nusa Tenggara Hospital in 2018. Five varieties of most used antibiotics based on their DDD/100 patient-days are ceftriaxone (60,71), levofloxacin (29,15), meropenem (16,10), metronidazole (11,00), dan amikacin (6,24). The percentage value of those antibiotics respectively is 45,44; 21,82; 12,05; 8,24; dan 4,67%. Based on all types of antibiotics, the range value of DDD/100 patient-days is 60,71- 0,05 DDD/100 patient-days

Keywords


Antibiotic, ATC/DDD, ICU, DDD/100 patient

References


Kee, J. L., & Hayes, E. R. Farmakologi Pendekatan Proses Keperawatan. Cetakan Pertama. EGC. Jakarta. 1996. p.325.

Kon, K., & Rai, M. Antibiotic Resistance Mechanisms and New Antimicrobial Approaches. Elsevier. 2016. p.3-6.

CDC. Antibiotic Resistance Threats in the United States. Centers for Disease Control and Prevention. US. Departement of Health and Human Services. US. 2019. p.3.

Kementerian kesehatan RI. Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 Tahun 2015 tentang Program Pengendalian Resistensi Antimikroba di Rumah Sakit. Kementerian Kesehatan Republik Indonesia. Kementerian Kesehatan RI. Jakarta. 2015.

Rogues, A. M., Dumartin, C., Amadéo, B., Venier, A. G., Marty, N., Parneix, P., & Gachie, J. P.. Relationship Between Rates of Antimicrobial Consumption and the Incidence of Antimicrobial Resistance in Staphylococcus aureus and Pseudomonas aeruginosa Isolates From 47 French Hospitals . Infection Control & Hospital Epidemiology. 2007, 28(12):1389–95.

WHO. Guidelines for ATC classification and DDD assignment. World Health Organization. Oslo. 2021. p.23-36.

Hanberger, H., Arman, D., Gill, H., Jindrák, V., Kalenic, S., Kurcz, A., Licker, M., Naaber, P., Scicluna, E. A., Vanis, V., & Walther, S. M. Surveillance of microbial resistance in European Intensive Care Units: A first report from the Care-ICU programme for improved infection control. Intensive Care Medicine. 2009, 35(1): 91–100.

Wardoyo, E. H., Suryani, D., & Sabrina, Y. Studi Rasionalitas Penggunaan Antibiotika Pasien Rawat Inap di RSUP NTB. Jurnal Kedokteran Unram. 2014. 4: 64–70.

ASHP. Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery. ASHP. US. 2013. p.762.

Rumah Sakit Umum Daerah Provinsi NTB. Panduan Penggunaan Antimikroba RSUD Provinsi NTB. RSUD Provinsi NTB. Mataram. 2019. p.15-26.

Prasil, P., Buchta, V., Paterova, P., & Hanovcova, I. Penetration of Ceftraixone Into the Cerebrospinal fluid and Its Relationship to Inflammatory Markers During Bacterial Meningitis. Clinical Microbiology and Infectious Disease. 2010, 16(2): 64-72.

Kementerian kesehatan RI. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Sepsis. Kementerian Kesehatan RI. 2017.

Kucers, A., Crowe, S., & McCarthy, J. Kucers' the Use of Antibiotics. CRC Press. Boca Raton. 2010. p.509.

Kementerian Kesehatan RI. Peraturan Menteri Kesehatan Republik Indonesia Nomor 2406/MENKES/PER/XXI /2011 tentang Pedoman Umum Penggunaan Antibiotik.. Kementerian Kesehatan RI. Jakarta. 2011.

Tjay, T. H., & Rahardja, K. Obat- obat Penting: Khasiat, Penggunaan dan Efek-efek Sampingnya. Elex Media Komputindo. Jakarta. 2008. p.75.

Downie, G., Mackenzie, J., Williams, A., Milne, C., & Bedi, R. Pharmacology and Medicines Management for Nurses. London. Churchill Livingstone Elsivier. 2007. p.301.

Kalil, A. C., Metersky, M. L., Klompas, M., Muscedere, J., Sweeney, D. A., Palmer, L. B., Napolitano, L. M., O’Grady, N. P., Bartlett, J. G., Carratala, J., Solh, A. A. E., Ewig, S., Fey, P. D., File, T. M., Restrepo, M. I., Roberts, J. A., Wateter, G. W., Cruse, P., Knight, S. L., & Brozek, J. L. Management of Adult with Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guideline by the Infectious Disease Society of America and American Thoracic Society. Infectious Disease Society of America. Omaha.2016.

Putri, S. C., Untari, E. K., & Yuswar, M. A. Profil Antibiotik Pada Pasien Intensive Care Unit (Icu) Di Rumah Sakit Dr. Soedarso Pontianak Periode Januari – Juni 2019. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN. 2019, 5(2): 293–303.

Yuniftiadi, F., Pujo, J. L., & Lestari, E. S. Kajian Rasionalitas Penggunaan Antibiotik di Intensive Care Unit RSUP Dr. Kariadi Semarang Periode Juli – Desember 2009. Microbiology. 2010, 1–15.

Wikantiananda, T., Tjahjadi, A. I., & Sudjud, R. W. Antibiotic Utilization Pattern in the Intensive Care Unit of Tertiary Hospital in West Java, Indonesia. International Journal of Integrated Health Sciences. 2019, 7(2): 81–7.

Saxena, S., Priyadarshi, M., Saxena, A., dan Singh, R. Antimicrobial Consumption and Bacterial Resistance Pattern in Patients Admitted in ICU at Tertiary Care Center. Journal of Infection and Public Health. 2019, 12(5): 695-99


Full Text: PDF

DOI: 10.24815/jks.v23i1.24796

Refbacks

  • There are currently no refbacks.