Fistula Perilimfatik: Pendekatan Biomarker Cochlin Tomoprotein (CTP) sebagai Peluang Modalitas Diagnostik
Abstract
Abstrak. Fistula perilimfatik (PLF) adalah kondisi dimana terdapat hubungan abnormal antara ruang telinga tengah dan kompartemen perilimfatik di telinga bagian dalam. Hubungan ini bisa disebabkan oleh adanya trauma, spontaneus, kongenital, pasca bedah atau akibat penyakit otologik seperti kolesteatoma. Diagnosis PLF setelah operasi relatif mudah, namun saat pasien datang dengan manifestasi klinis klasik akan membutuhkan pemeriksaan yang lengkap agar mampu menyingkirkan penyebab lainnya. Kebanyakan metode yang digunakan untuk mengidentifikasi PLF kurang sensitif dan spesifitas diagnosisnya tidak memberikan hasil yang konsisten. Kemajuan teknik pencitraan dan teknologi baru dengan pendekatan biomarker saat ini telah menjadi peluang modalitas yang baik dalam mendefinisikan dan mendiagnosis PLF, meskipun anamnesis dan pemeriksaan fisik yang tepat adalah elemen kunci untuk pemeriksaan pasien dengan fistula perilimfatik.
Kata Kunci: Fistula Perilimfatik, Biomarker, Cochlin Tomoprotein
Abstract. Perilymph fistula (PLF) is a condition where there is an abnormal connection between the middle ear space and the perilymphatic compartment in the inner ear. This relationship caused by trauma, spontaneous, congenital, post-surgery or due to otologic disease such as cholesteatoma. Diagnosis of PLF after surgery is relatively easy, however when a patient presents with classic clinical manifestations, a whole examination is required to rule out other causes. Most of the methods used to identify PLF were lack of sensitivity and the diagnostic specificity were inconsistent. Advanced imaging techniques and new technologies approache biomarker have now emerge as an excellent modality and opportunity in defining and diagnosing PLF, despite the fact that proper anamnesis and physical examination are the key elements in the examination of patients with perilymph fistula.
Keywords: Perilymph fistula (PLF), Biomarkers, Cochlin Tomoprotein
Keywords
References
Richard R. Gacek. Anatomy of the Auditory and Vestibular Systems. Ballenger ’ s Head And Neck Surgery. People’s Medical Publishing House-USA; 2016. 65 p.
Sherwood L. Fisiologi Manusia dari: dari sel ke sistem. 2014. 231 p.
Buku Ajar Ilmu Kesehatan THT-KL FKUI. 6th ed. Jakarta: Badan Penerbit FKUI;
Deveze A, Matsuda H, Elziere M, Ikezono T. Diagnosis and treatment of perilymphatic fistula. Adv Otorhinolaryngol. 2018;81:133–45.
Venkatasamy A, Al Z, Anne O, Aurélie K, Georges K, Riehm S, et al. CT and MRI for the diagnosis of perilymphatic fistula : a study of 17 surgically confirmed patients. Eur Arch Oto-Rhino-Laryngology [Internet]. 2020;(0123456789). Available from: https://doi.org/10.1007/s00405-020-05820-3
Al-qahtani A. Textbook of Clinical Otolaryngology. Textbook of Clinical Otolaryngology. 2021.
Sarna B, Abouzari M, Merna C, Jamshidi S, Saber T, Djalilian HR. Perilymphatic Fistula: A Review of Classification, Etiology, Diagnosis, and Treatment. Front Neurol. 2020;11(September):1–11.
Alzahrani M, Fadous R, Dufour JJ, Saliba I. Perilymphatic fistulas: can we predict the diagnosis? Eur Arch Oto-Rhino-Laryngology. 2015;272(8):1885–91.
Snell RS. Anatomi Klinis: Berdasarkan Sistem. 6th ed. EGC; 2012.
Setyo Nugroho P, Wiyadi H. Anatomi Dan Fisiologi Pendengaran Perifer. J THT-KL [Internet]. 2012;2(2):76–85. Available from: file:///Users/macintoshhd/Desktop/anat dan fisio telinga.pdf
Frank H N. Atlas Anatomi Manusia Bahasa Latin/ Indonesia Edisi 6. Indonesia. 6th ed. Elsevier; 2016.
Paulsen FW. Sobotta Atlas Anatomi Manusia : Kepala, Leher, dan Neuroanatomi Jilid 1. 23rd ed. 2013.
Lim R, Brichta AM. Anatomical and physiological development of the human inner ear. Hear Res [Internet]. 2016;338:9–21. Available from: http://dx.doi.org/10.1016/j.heares.2016.02.004
Ahn J, Son SE, Choi JE, Cho YS, Chung WH. Surgical Outcomes on Hearing and Vestibular Symptoms in Barotraumatic Perilymphatic Fistula. Otol Neurotol. 2019;40(4):e356–63.
Kita AE, Kim I, Ishiyama G. Perilymphatic Fistula After Penetrating Ear Trauma. 2019;115–8.
Prisman E, Ramsden JD, Blaser S, Papsin B. Traumatic perilymphatic fistula with pneumolabyrinth: Diagnosis and management. Laryngoscope. 2011;121(4):856–9.
Matsuda H, Sakamoto K, Matsumura T, Saito S, Fukushima K, Nishio S, et al. A nationwide multicenter study of the Cochlin tomo-protein detection test : clinical characteristics of perilymphatic fistula cases. 2017;6489.
Lee K, Ochi N, Yamahara K, Makino K, Ikezono T. A Case of Perilymphatic Fistula with Inner Ear Anomaly Diagnosed Preoperatively by the Cochlin-Tomoprotein Detection Test. Case Rep Otolaryngol. 2020;2020(Figure 3):1–4.
Bozorg Grayeli A, Bensimon JL, Guyon M, Aho-Glele S, Toupet M. Detection of perilymphatic fistula in labyrinthine windows by virtual endoscopy and variation of reconstruction thresholds on CT scan. Acta Otolaryngol [Internet]. 2020;140(4):270–6. Available from: https://doi.org/10.1080/00016489.2020.1715472
Kataoka Y, Ikezono T, Fukushima K, Yuen K, Maeda Y, Sugaya A, et al. Cochlin-tomoprotein (CTP) detection test identified perilymph leakage preoperatively in revision stapes surgery. Auris Nasus Larynx [Internet]. 2013;40(4):422–4. Available from: http://dx.doi.org/10.1016/j.anl.2012.08.001
Oğuz KUŞCU1, MD; Serap KUŞCU2, MD; Övsen ÖNAY1, MD; Rıza Önder GÜNAYDIN1 MTY. Clinical Study Outcomes And The Management Of Perilympthatic Fistula At Tertiary Center. 2015;14(4):82–8.
Omichi R, Kariya S, Maeda Y, Nishizaki K. Transcanal endoscopic ear surgery for perilymphatic fistula after electric acoustic stimulation. Auris Nasus Larynx [Internet]. 2017. Available from: https://doi.org/10.1016/j.anl.2017.10.004
DOI: 10.24815/jks.v23i1.30283
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