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Analysis of cardiovascular risk factors as predictors for coronary artery disease stenosis severity

Saugi Abduh, Rheza Rizaldy

Abstract


The risk factors for coronary artery disease (CAD) include age, hypertension, diabetes mellitus (DM), total cholesterol levels, smoking status, and obesity, with central obesity being of particular concern. However, there is a lack of research on the connection between CAD risk factors and the severity of stenosis in the Indonesian population, specifically in Central Java, as assessed by the Gensini score. The purpose of this study was to analyze hypertension, diabetes mellitus, total cholesterol levels, smoking status, body mass index (BMI), and waist circumference (LP) as predictors of the severity of CAD stenosis assessed using the Gensini score. A cross-sectional study was conducted on CAD patients at RSI Sultan Agung for the period of 2018-2021. The risk factors for CAD studied were age, gender, blood glucose (GDS), blood pressure, total cholesterol, smoking status, BMI, and LP. The degree of stenosis was grouped using gensini score into severe stenosis if the vessel narrowing was >40% and mild-moderate if  ≤40%. The data were analyzed using logistic regression test. Gender, smoking status, BMI, and LP had a significant relationship to the severity of stenosis as assessed using the Gensini score. The results of multivariate analysis showed that gender, smoking status, BMI, and LP could increase the risk of CAD with the severity of severe stenosis as much as 2,774; 1,959; 2,269; and 1,883 times respectively. Gender, smoking status, BMI, and LP can be used as predictors of the severity of coronary artery disease stenosis as assessed using the Gensini score.

Keywords


CAD; gensini score; cardiovascular risk factors

References


Bauersachs R, Zeymer U, Brière JB, Marre C, Bowrin K, Huelsebeck M. Burden of Coronary Artery Disease and Peripheral Artery Disease: A Literature Review. Cardiovasc Ther. 2019;2019:8295054.

Hajar R. Risk Factors for Coronary Artery Disease: Historical Perspectives. Heart Views Off J Gulf Heart Assoc. 2017;18(3):109–14.

Nam GE, Park HS. Perspective on Diagnostic Criteria for Obesity and Abdominal Obesity in Korean Adults. J Obes Metab Syndr. 2018 Sep;27(3):134–42.

Flint AJ, Rexrode KM, Hu FB, Glynn RJ, Caspard H, Manson JE, et al. Body mass index, waist circumference, and risk of coronary heart disease: a prospective study among men and women. Obes Res Clin Pract. 2010 Jul;4(3):e171–81.

Kosyakovsky LB, Austin PC, Ross HJ, Wang X, Abdel-Qadir H,

Goodman SG, et al. Early invasive coronary angiography and acute ischaemic heart failure outcomes. Eur Heart J. 2021 Sep;42(36):3756–66.

Hashemi M, Karimian M, Nilforoush P, Taheri M, Behjati M. Evaluation of the predictive value of Gensini score on determination of severity of coronary artery disease in cases with left bundle branch block. Comp Clin Pathol. 2018;27(5):1297–301.

Omidi N, Sadeghian S, Salarifar M, Jalali A, Abbasi SH, Yavari N, et al. Relationship between the Severity of Coronary Artery Disease and Cardiovascular Risk Factors in Acute Coronary Syndrome: Based on

Tehran Heart Center’s Data Registry. J Tehran Heart Cent. 2020 Oct;15(4):165–70.

Rodgers JL, Jones J, Bolleddu SI, Vanthenapalli S, Rodgers LE, Shah K, et al. Cardiovascular Risks Associated with Gender and Aging. J Cardiovasc Dev Dis. 2019 Apr;6(2).

Hernandez-Vila E. A review of the JNC 8 Blood Pressure Guideline. Tex Heart Inst J. 2015 Jun;42(3):226–8.

Diagnosis and classification of diabetes mellitus. Diabetes Care. 2010 Jan;33 Suppl 1(Suppl 1):S62-9.

Lim JU, Lee JH, Kim JS, Hwang Y Il, Kim TH, Lim SY, et al. Comparison of World Health Organization and Asia-Pacific body mass index classifications in COPD patients. Int J Chron Obstruct Pulmon Dis. 2017;12:2465–75.

Morris PD, Channer KS. Testosterone and cardiovascular disease in men. Asian J Androl. 2012 May;14(3):428–35.

Corona G, Monami M, Rastrelli G, Aversa A, Sforza A, Lenzi A, et al. Type 2 diabetes mellitus and testosterone: a meta-analysis study. Int J Androl. 2011 Dec;34(6 Pt 1):528–40.

Golbidi S, Edvinsson L, Laher I. Smoking and Endothelial Dysfunction. Curr Vasc Pharmacol. 2020;18(1):1–11.

Benowitz NL, Burbank AD. Cardiovascular toxicity of nicotine: Implications for electronic cigarette use. Trends Cardiovasc Med. 2016 Aug;26(6):515–23.

Merianos AL, Jandarov RA, Khoury JC, Mahabee-Gittens EM. Tobacco Smoke Exposure Association With Lipid Profiles and Adiposity Among U.S. Adolescents. J Adolesc Health Off Publ Soc Adolesc Med. 2018 Apr;62(4):463–70.

Salehi N, Janjani P, Tadbiri H, Rozbahani M, Jalilian M. Effect of cigarette smoking on coronary arteries and pattern and severity of coronary artery disease: a review. J Int Med Res. 2021 Dec;49(12):3000605211059893.

Executive summary of the clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. Arch Intern Med. 1998 Sep;158(17):1855–67.

Owolabi EO, Ter Goon D, Adeniyi OV. Central obesity and normal-weight central obesity among adults attending healthcare facilities in Buffalo City Metropolitan Municipality, South Africa: a cross-sectional study. J Health Popul Nutr. 2017 Dec;36(1):54.

Henning RJ. Obesity and obesity-induced inflammatory disease contribute to atherosclerosis: a review of the pathophysiology and treatment of obesity. Am J Cardiovasc Dis. 2021;11(4):504–29.

Van de Voorde J, Pauwels B, Boydens C, Decaluwé K. Adipocytokines in relation to cardiovascular disease. Metabolism. 2013 Nov;62(11):1513–21.

Rashiti P, Behluli I, Bytyçi AR. Assessment of the correlation between severity of coronary artery disease and waist-hip ratio. Open Access Maced J Med Sci. 2017;5(7):929–33.


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DOI: 10.24815/jks.v23i2.31688

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