Identify Chemical Compounds of Wedelia biflora and Test Their Bioactivity as Antiplasmodium Berghei

Abstract

The aims of the research is to identify chemical compounds of leaf Sernai (Wedelia biflora) and test their bioactivity as antiplasmodium
against of Plasmodium berghei. Extraction of the compounds from the Wedila biflora leaf was done with methanol. To observe the bioactive
potency of the Wedelia biflora extract antiplasmodium test against with The 4-day test method was done. The Phytochemical test results using the
Lieberman-Burchard reagent positive for triterpenoids compounds and analysis by GC-MS chromatogram identified 45 compounds with an
abundance peak maximum of 27.92% which is identified in the data base as kaur-16-en-18-oic acid. Wedelia biflora leaf extract potentially
active as antiplasmodium with IC
values = 39.952 mg / kg BW.
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Key words: antiplasmodium, GC-MS, Plasmodium berghei, Wedelia bifolra
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