EFEK PENGGUNAAN KETAMIN-XILAZIN DAN PROPOFOL TERHADAP DENYUT JANTUNG DAN PERNAFASAN PADA ANJING JANTAN LOKAL (Canis familiaris) (Effect of Ketamine-Xylazine and Propofol on Heart Rate and Breathing Frequency of Local Male Dog (Canis familiaris))

Abstract

The purpose of this study was to determine the effect of using ketamine-xylazin and propofol on heart rate and breathing in local male dogs (Canis familiaris). Six male dogs with average body weight ±2-3 kg were divided into 2 treatment groups, each group was subcutaneously injected with of atropine sulfate at dose of 0.04 mg/kg as premedication prior to anesthetic administration. The first group (K1) was intravenously injected with anesthetic combination of ketamine-xylazine at dose of 5.5 mg/kg and 1 mg/kg, respectively. The second group (K2) was given propofol at dose of 6.6 mg/kg intravenously. The heart rate and breathing were directly calculated using stethoscope and stopwatch with 10 minutes interval. Data were analyzed statistically using analysis of variance (Anova) with split-splot design and if there is a difference between the two groups followed by least significant difference test (LSD). The administration of ketamine-xylazin (K I) significantly (P<0.05) increase the respiratory frequency compared to propofol administration (K2). The interaction between time and precise observation of K1 and K2 on 30 minute observation (W3) showed significant differences (P<0.05). While on other time observations did not reveal any differences in the interaction between time and observation (P>0.05). It can be concluded that there is no difference effects of given ketamine-xylazin and propofol against heart rate on local male dogs. But there was difference effect of administration ketamine-xylazin and propofol on respiratory frequency on local male dogs.