1. Home
  2. Volume 19 Number 3, October 2019
  3. Suryawati

TRIGONELLA FOENUM : A REVIEW OF HYPOGLYCEMIC ACTIVITY

Suryawati Suryawati, Safrida Safrida, Firdausa Sarah, Azizah Vonna, Vera Dewi Mulia

Abstract


Treatment of diabetes mellitus is intended to reduce the risk of blindness, kidney failure, neuropathy and heart disease that can develop due to the chronic increase in the blood glucose level. The selected hypoglycemic agents should be effective, safe and readily available. The widely used agents work by interrupting enzymes responsible for glucose regulation. Those enzymes are α-amilase, α-glucosidase, dipeptidyl peptidase-IV, aldose reductase and angiotensin converting enzyme. A medicinal plant, fenugreek (Trigonella foenum-graecum) has been used as an antidiabetic folk medicine. This review provides information related to in vitro studies showing antihyperglycemic activity of fenugreek along with an in vivo study in animals. In addition, potential phytochemicals that have been isolated from this plant are described and play a role in the searching for the most potent agents for diabetes mellitus therapy.


Keywords


diabetes mellitus, enzymes, Trigonella foenum-graecum

References


Asmat U, Abad K, Ismail K. 2016. Diabetes mellitus and oxidative stress—A concise review. Saudi Pharm J [Internet]. [cited 2017 Nov 21];24(5):547–53. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27752226 doi: 10.1016/j.jsps.2015.03.013

Oshikoya KA, Senbanjo IO, Njokanma OF, Soipe A. 2008. Use of complementary and alternative medicines for children with chronic health conditions in Lagos, Nigeria. BMC Complement Altern Med [Internet]. [cited 2017 Nov 21];8(1):66. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19113999 doi: 10.1186/1472-6882-8-66

Dey B, Mitra A, Katakam P, Singla RK. 2014. Exploration of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptus Spp. by in vitro assays. World J Diabetes [Internet]. [cited 2017 Nov 22] 5(2): 209-218. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990318/ doi: 10.4239/wjd.v5.i2.209

Tim TK. Edible medicinal and non-medicinal plants: Volume 4, Fruits. Edible Med Non-Medicinal Plants Vol 4, Fruits. 2012;2:906-924

Ganeshpurkar A, Diwedi V, Bhardwaj Y. 2013. In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract. Ayu [Internet]. [cited 2017 Nov 21];34(1):109–12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24049415 doi: 10.4103/0974-8520.115446

Salehi P, Asghari B, Esmaeili MA, Dehghan H, Ghazi I. 2013. α-Glucosidase and α-amylase inhibitory effect and antioxidant activity of ten plant extracts traditionally used in Iran for diabetes. J Med Plants Res [Internet]. [cited 2017 Nov 21];7(6):257–66. Available from: http://www.academicjournals.org/JMPR doi: 10.5897/JMPR11.1320

Riyanti S, Suganda AG, Sukandar EY. 2016. Dipeptidyl peptidase-IV inhibitory activity of some Indonesian medicinal plants. Asian J Pharm Clin Res [Internet]. [cited 2017 Nov 21];9(2):375–7. Available from: https://www.researchgate.net/publication/317830722_Dipeptidyl_peptidase-IV_inhibitory_activity_of_some_Indonesian_medicinal_plants

Veeresham C, Rama Rao A, Asres K. 2014. Aldose reductase inhibitors of plant origin. Phyther Res [Internet]. [cited 2017 Nov 21];28(3):317–33. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23674239 doi: 10.1002/ptr.5000

Hamden K, Jaouadi B, Carreau S, Bejar S, Elfeki A. 2010. Inhibitory effect of fenugreek galactomannan on digestive enzymes related to diabetes, hyperlipidemia, and liver-kidney dysfunctions. Biotechnol Bioprocess Eng [Internet]. [cited 2017 Nov 21];15(3):407–13. Available from: http://link.springer.com/10.1007/s12257-009-3037-9 doi: 10.1007/s12257-009-3037-9

Sharma A, Paliwal G, Upadhyay N, Tiwari A. 2015. Therapeutic stimulation of GLP-1 and GIP protein with DPP-4 inhibitors for type-2 diabetes treatment. J Diabetes Metab Disord [Internet]. [cited 2017 Nov 21];14:15. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26473146 doi: 10.1186/s40200-015-0143-4

Deacon CF. 2011. Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review. Diabetes, Obes Metab [Internet]. [cited 2017 Nov 21];13(1):7–18. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21114598 doi: 10.1111/j.1463-1326.2010.01306.x

Antony P, Vijayan R. 2015. Identification of novel aldose reductase inhibitors from spices: A molecular docking and simulation study. Zheng J, editor. PLoS One [Internet]. [cited 2017 Nov 21];10(9):e0138186. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26384019 doi: 10.1371/journal.pone.0138186

Hamden K, Keskes H, Belhaj S, Mnafgui K, feki A, Allouche N. 2011. Inhibitory potential of omega-3 fatty and fenugreek essential oil on key enzymes of carbohydrate-digestion and hypertension in diabetes rats. Lipids Health Dis [Internet]. [cited 2017 Nov 21];10(1):226. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22142357 doi: 10.1186/1476-511X-10-226

Subhashini N, Thangathirupathi A, Lavanya N. 2011. Antioxidant activity of Trigonella foenum graecum using various in vitro and ex vivo models. Int J Pharm Pharm Sci [Internet]. [cited 2017 Nov 21];3(2):96–102. Available from: http://www.ijppsjournal.com/Vol3Issue2/1195.pdf

Al-Khateeb E, Hamadi SA, Al-Hakeemi AAN, Abu-Taha M, Al-Rawi N. 2012. Hypoglycemic effect of trigonelline isolated from iraqi fenugreek seeds in normal and alloxan-diabetic rabbits. Eur Sci J December Ed [Internet]. [cited 2017 Nov 21];8(30):1857–7881. Available from: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.378.1558&rep=rep1&type=pdf

Gaikwad SB, Krishna Mohan G, Sandhya Rani M. 2014. Phytochemicals for diabetes management. Pharm Crop [Internet]. [cited 2017 Nov 21];5:11–28. Available from: https://benthamopen.com/contents/pdf/TOPHARMCJ/TOPHARMCJ-5-11.pdf

Fuller S, Stephens JM. 2015. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr [Internet]. [cited 2017 Nov 21];6(2):189–97. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25770257 doi: 10.3945/an.114.007807

Kamble H, Kandhare AD, Bodhankar S, Mohan V, Thakurdesai P. 2013. Effect of low molecular weight galactomannans from fenugreek seeds on animal models of diabetes mellitus. Biomed Aging Pathol [Internet]. [cited 2017 Nov 21];3(3):145–51. Available from: http://linkinghub.elsevier.com/retrieve/pii/S2210522013000294 doi: 10.1016/j.biomag.2013.06.002

Subramanian SP, Prasath GS. 2014. Antidiabetic and antidyslipidemic nature of trigonelline, a major alkaloid of fenugreek seeds studied in high-fat-fed and low-dose streptozotocin-induced experimental diabetic rats. Biomed Prev Nutr [Internet]. [cited 2017 Nov 21];4(4):475–80. Available from: http://linkinghub.elsevier.com/retrieve/pii/S2210523914000610 doi: 10.1016/j.bionut.2014.07.001

Avalos-Soriano A, De la Cruz-Cordero R, Rosado J, Garcia-Gasca T. 2016. 4-Hydroxyisoleucine from fenugreek (Trigonella foenum-graecum): effects on insulin resistance associated with obesity. Molecules [Internet]. [cited 2017 Nov 21];21(11):1596. Available from: http://www.ncbi.nlm.nih.gov/pubmed/27879673 doi: 10.3390/molecules21111596

Broca C, Gross R, Petit P, Sauvaire Y, Manteghetti M, Tournier M, et al. 1999. 4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties. Am J Physiol [Internet]. [cited 2017 Nov 21];277(4 Pt 1):E617-23. Available from: http://www.ncbi.nlm.nih.gov/pubmed/10516120

Rawat AK, Korthikunta V, Gautam S, Pal S, Tadigoppula N, Tamrakar AK, et al. 2014. 4-Hydroxyisoleucine improves insulin resistance by promoting mitochondrial biogenesis and act through AMPK and Akt dependent pathway. Fitoterapia [Internet]. [cited 2017 Nov 21];99:307–17. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25454462 doi: 10.1016/j.fitote.2014.10.006

Kim J-H, Kang M-J, Choi H-N, Jeong S-M, Lee Y-M, Kim J-I. 2011. Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus. Nutr Res Pract [Internet]. [cited 2017 Nov 21];5(2):107. Available from: http://www.ncbi.nlm.nih.gov/pubmed/21556223 doi: 10.4162/nrp.2011.5.2.107

Srichamroen A, Field CJ, Thomson ABR, Basu TK. 2008. The modifying effects of galactomannan from Canadian-grown Fenugreek (Trigonella foenum-graecum L.) on the glycemic and lipidemic status in rats. J Clin Biochem Nutr J Clin Biochem Nutr Soc Free Radic Res Japan Kyoto [Internet]. [cited 2017 Nov 21];43(10):167–74. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581758/pdf/jcbn-43-167.pdf doi: 10.3164/jcbn.2008060


Full Text: PDF

DOI: 10.24815/jn.v19i3.13405

Refbacks

  • There are currently no refbacks.