28. The Potential of Red Watermelon Extract (Citrullus vulgaris) to Decrease Blood Glucose Levels in Mice (Mus musculus) Were Exposed with Cigarette Smoke

Irfani Rahmi, Roslizawaty Roslizawaty, Azhar Azhar, Razali Daud, Syafruddin Syafruddin, Ismail Ismail

Abstract


The aim of this research was to find out the potential of red watermelon extract (Citrullus vulgaris) to lower the high blood glucose levels in mice (Mus musculus) as a result of exposure to cigarette smoke. sample was 15 mice  which are divided into 3 treatment groups, each group consists of 5 mice. Positive group as (KP) is the treated group with one cigarette exposure per day. Treatment group 1 as (K1) is the treated group with exposure to one cigarette and 22 mg dose extract of red watermelon of each mice per day. Then the treatment group 2 as (K2) is the group that was given exposure to one cigarette and 44 mg dose extract of red watermelon of each mice per day. Blood glucose testing on mice was conducted on days 0, 15, and  30 after giving the exposure of cigarette smoke and extract of red watermelon. The result showed that (KP) has significant different with (K1) and (K2) (P<0.05), meanwhile (K1) and (K2) was not significant different (P>0.05). The results also showed H-0 was significantly different from the H-15 and H-30 (P <0.05), while the H-15 and H-30 was not significantly different (P> 0.05). From the results, it can be concluded that 22 mg and 44 mg of red watermelon extract are not able to lower the high blood glucose levels on mice which were exposed to cigarette smoke..    

Keywords


blood glucose; lycopen; nicotin; cigarette smoke; red watermelon extract

Full Text:

PDF

References


Batubara, I.V.D., B, Wantouw. dan L. Tendean. 2013. Pengaruh paparan asap rokok kretek terhadap kualitas spermatozoa mencit jantan (Mus musculus). Jurnal e-Biomedik. 1(1):2-3.

Brotosunaryo, O.A.S. 2002. Pemberdayaan petani kelapa. Journal Cocotech Special. 26(3):42-45.

Chairunnisa, R. 2012. Pengaruh jumlah pasta tomat terhadap penurunan kadar gula darah pada mencit diabetes. Jurnal Teknologi Industri Pertanian. 1(1):1-2.

Frati, A.C., F. Iniestra, dan C.R. Ariza. 1996. Acute effect of cigarette smoking on glucose tolerance and other cardiovascular risk factors. Jurnal Diabetes Care. 19(2):13-114.

Hargono, F.R., P.M. Lintong, dan C.F. Kairupan. 2013. Gambaran histopatologik testis mencit swiss (Mus musculus) yang diberi kedelai (Glycine max) dan paparan dengan asap rokok. Jurnal e-Biomedik. 1(2):2.

Ismayanti., S. Bahri, dan Nurhaeni. 2013. Kajian kadar fenolat dan aktivitas antioksidan jus kulit buah semangka (Citrullus lanatus). Online Jurnal of

Natural Science. 2(2):36-45.

Kailaku, S.I., K.T. Dewandari, dan Sunarmani. 2007. Potensi likopen dalam tomat untuk kesehatan. Buletin Teknologi Pascapanen Pertanian. 3(7):51-52.

Leoni, A.P. 2012. Hubungan Umur, Asupan Protein, dan Faktor Lainnya dengan Kadar Glukosa Darah Puasa pada Pegawai Satlantas dan Sumda di Polresta Depok tahun 2012. Skripsi. Fakultas Kesehatan Masyarakat Universitas Indonesia, Jakarta.

Naz, A., M.S. Butt, M.T. Sultan, M.M.N. Qayyum, dan R.S. Niaz. 2014. Watermelon lycopene and allied health claims. Excli Journal. 13(1):651-660.

Nugrahani, S.S. 2012. Ekstrak akar, batang, dan daun herba meniram dalam menurunkan kadar glukosa darah. Jurnal KEMAS. 8(1):51-59.

Padmaningrum, R.T. 2007. Rokok Mengandung Zat Adiktif yang Berbahaya bagi Kesehatan. PPM Regina Tutik Padmaningrum. Jurdik. Kimia. UNY. 13(2):12-15.

Sudoyo, A.W., B. Setiyohadi, I.K. Alwi, S. Marcellus, dan S. Setati. 2009. Buku Ajar Ilmu Penyakit Dalam. Edisi Kelima. InternaPublishing, Jakarta.

Suparmin, S. 2010. Beda Kadar Glukosa Darah Pada Pria Perokok dan Bukan Perokok Tembakau Usia 20-60 Tahun di Salemba Tahun 2009-2010. Skripsi. Fakultas Kedokteran Universitas Indonesia, Jakarta.

Susanna, D., B. Hartono, dan H. Fauzan. 2003. Penentuan kadar nikotin dalam asap rokok. Jurnal Makara Kesehatan. 7(2):3.

Studiawan, H. dan M.H. Santosa. 2005. Uji aktivitas penurunan kadar glukosa darah ekstrak daun eugenia polyantha pada mencit yang diinduksi aloksan. Media Kedokteran Hewan. 21(5):2.

Targher, G. 2005. How does smoking affect insulin sensitivity. J. Diabetes Voice. 50(1):23-50.

Wang, S.Y. 2006. Effect of Pre-harvest Conditions on Antioxidant Capacity in Fruits. Agricultural Research Service. US Department of Agriculture Beltsville, USA.

Winarsih, H. 2007. Antioksidan Alami dan Radikal Bebas. Kanisius, Yogyakarta.




DOI: https://doi.org/10.21157/j.med.vet..v13i2.3544

Article Metrics

Abstract view : 0 times
PDF - 0 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2019 by author and J. Med. Vet.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Creative Commons License
J. Med. Vet. is licensed under a Creative Commons Attribution 4.0 International License.